DDX3X [The Human Chemical-Genetic Interaction Map Project]

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======= DDX3X =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DDX3X
  * **<color #00a2e8>Official Name</color>**: DEAD-box helicase 3 X-linked
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1654|1654]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00571|O00571]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DDX3X&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DDX3X|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300160|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the large DEAD-box protein family, that is defined by the presence of the conserved Asp-Glu-Ala-Asp (DEAD) motif, and has ATP-dependent RNA helicase activity. This protein has been reported to display a high level of RNA-independent ATPase activity, and unlike most DEAD-box helicases, the ATPase activity is thought to be stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. This gene has a paralog located in the nonrecombining region of the Y chromosome. Pseudogenes sharing similarity to both this gene and the DDX3Y paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo- and deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double-stranded DNA with a preference for 5'- single-stranded DNA overhangs. Is involved in several steps of gene expression, such as transcription, mRNA maturation, mRNA export and translation. However, the exact mechanisms are not known and some functions may be specific for a subset of mRNAs. Involved in transcriptional regulation. Can enhance transcription from the CDKN1A/WAF1 promoter in a SP1-dependent manner. Found associated with the E-cadherin promoter and can down-regulate transcription from the promoter. Involved in regulation of translation initiation. Proposed to be involved in positive regulation of translation such as of cyclin E1/CCNE1 mRNA and specifically of mRNAs containing complex secondary structures in their 5'UTRs; these functions seem to require RNA helicase activity. Specifically promotes translation of a subset of viral and cellular mRNAs carrying a 5'proximal stem-loop structure in their 5'UTRs and cooperates with the eIF4F complex. Proposed to act prior to 43S ribosomal scanning and to locally destabilize these RNA structures to allow recognition of the mRNA cap or loading onto the 40S subunit. After association with 40S ribosomal subunits seems to be involved in the functional assembly of 80S ribosomes; the function seems to cover translation of mRNAs with structured and non-structured 5'UTRs and is independent of RNA helicase activity. Also proposed to inhibit cap-dependent translation by competetive interaction with EIF4E which can block the EIF4E:EIF4G complex formation. Proposed to be involved in stress response and stress granule assembly; the function is independent of RNA helicase activity and seems to involve association with EIF4E. May be involved in nuclear export of specific mRNAs but not in bulk mRNA export via interactions with XPO1 and NXF1. Also associates with polyadenylated mRNAs independently of NXF1. Associates with spliced mRNAs in an exon junction complex (EJC)-dependent manner and seems not to be directly involved in splicing. May be involved in nuclear mRNA export by association with DDX5 and regulating its nuclear location. Involved in innate immune signaling promoting the production of type I interferon (IFN-alpha and IFN-beta); proposed to act as viral RNA sensor, signaling intermediate and transcriptional coactivator. Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, plays a role of scaffolding adapter that links IKBKE and IRF3 and coordinates their activation. Also found associated with IFNB promoters; the function is independent of IRF3. Can bind to viral RNAs and via association with MAVS/IPS1 and DDX58/RIG-I is thought to induce signaling in early stages of infection. Involved in regulation of apoptosis. May be required for activation of the intrinsic but inhibit activation of the extrinsic apoptotic pathway. Acts as an antiapoptotic protein through association with GSK3A/B and BIRC2 in an apoptosis antagonizing signaling complex; activation of death receptors promotes caspase-dependent cleavage of BIRC2 and DDX3X and relieves the inhibition. May be involved in mitotic chromosome segregation. Is an allosteric activator of CSNK1E, it stimulates CSNK1E-mediated phosphorylation of DVL2 and is involved in the positive regulation of canonical Wnt signaling (PubMed:23413191). {ECO:0000269|PubMed:16301996, ECO:0000269|PubMed:16818630, ECO:0000269|PubMed:17357160, ECO:0000269|PubMed:17667941, ECO:0000269|PubMed:18264132, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:18628297, ECO:0000269|PubMed:18636090, ECO:0000269|PubMed:18846110, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20375222, ECO:0000269|PubMed:20657822, ECO:0000269|PubMed:20837705, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:21730191, ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:22034099, ECO:0000269|PubMed:22323517, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:23413191, ECO:0000269|PubMed:23478265}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DEAD|
|Helicase C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CTPase activity|
|positive regulation of chemokine (C-C motif) ligand 5 production|
|RNA strand annealing activity|
|mature ribosome assembly|
|protein localization to cytoplasmic stress granule|
|nucleoside-triphosphatase activity|
|RNA secondary structure unwinding|
|regulation of chemokine (C-C motif) ligand 5 production|
|eukaryotic initiation factor 4E binding|
|P granule|
|eukaryotic translation initiation factor 3 complex|
|stress granule assembly|
|ribosomal small subunit binding|
|cellular response to arsenic-containing substance|
|translation initiation factor binding|
|RNA stem-loop binding|
|poly(A) binding|
|mRNA 5-UTR binding|
|protein serine/threonine kinase activator activity|
|positive regulation of translational initiation|
|positive regulation of interferon-beta production|
|response to arsenic-containing substance|
|extrinsic apoptotic signaling pathway via death domain receptors|
|positive regulation of viral genome replication|
|cellular response to osmotic stress|
|positive regulation of G1/S transition of mitotic cell cycle|
|cytosolic small ribosomal subunit|
|positive regulation of cell cycle G1/S phase transition|
|regulation of interferon-beta production|
|positive regulation of chemokine production|
|DNA helicase activity|
|positive regulation of viral life cycle|
|RNA helicase activity|
|ribosome assembly|
|cytoplasmic stress granule|
|positive regulation of mitotic cell cycle phase transition|
|response to osmotic stress|
|regulation of chemokine production|
|positive regulation of type I interferon production|
|regulation of translational initiation|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of cysteine-type endopeptidase activity|
|regulation of viral genome replication|
|positive regulation of cell cycle phase transition|
|negative regulation of intrinsic apoptotic signaling pathway|
|extrinsic apoptotic signaling pathway|
|positive regulation of viral process|
|DNA duplex unwinding|
|secretory granule lumen|
|DNA geometric change|
|ficolin-1-rich granule lumen|
|positive regulation of translation|
|regulation of type I interferon production|
|negative regulation of translation|
|negative regulation of protein complex assembly|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|translational initiation|
|positive regulation of canonical Wnt signaling pathway|
|regulation of viral life cycle|
|negative regulation of cellular amide metabolic process|
|intrinsic apoptotic signaling pathway|
|regulation of G1/S transition of mitotic cell cycle|
|positive regulation of mitotic cell cycle|
|positive regulation of cellular amide metabolic process|
|positive regulation of cysteine-type endopeptidase activity|
|regulation of intrinsic apoptotic signaling pathway|
|mitochondrial outer membrane|
|positive regulation of cell growth|
|regulation of cell cycle G1/S phase transition|
|positive regulation of endopeptidase activity|
|positive regulation of Wnt signaling pathway|
|negative regulation of cell growth|
|positive regulation of peptidase activity|
|regulation of viral process|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|negative regulation of apoptotic signaling pathway|
|ribonucleoprotein complex assembly|
|ATPase activity|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of growth|
|negative regulation of endopeptidase activity|
|ribonucleoprotein complex subunit organization|
|negative regulation of peptidase activity|
|positive regulation of growth|
|chromosome segregation|
|response to virus|
|regulation of canonical Wnt signaling pathway|
|apoptotic signaling pathway|
|positive regulation of cell cycle process|
|DNA conformation change|
|ribosome biogenesis|
|cadherin binding|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|GTPase activity|
|transcription factor binding|
|positive regulation of protein serine/threonine kinase activity|
|regulation of translation|
|negative regulation of proteolysis|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|positive regulation of proteolysis|
|regulation of Wnt signaling pathway|
|positive regulation of cell cycle|
|translation|
|regulation of apoptotic signaling pathway|
|nuclear speck|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|regulation of mitotic cell cycle phase transition|
|regulation of cell growth|
|regulation of endopeptidase activity|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of peptidase activity|
|regulation of cell cycle phase transition|
|positive regulation of cytokine production|
|regulation of protein complex assembly|
|negative regulation of hydrolase activity|
|ribonucleoprotein complex biogenesis|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|negative regulation of intracellular signal transduction|
|positive regulation of multi-organism process|
|leukocyte degranulation|
|regulation of protein serine/threonine kinase activity|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|positive regulation of protein kinase activity|
|positive regulation of kinase activity|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of mitotic cell cycle|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of transferase activity|
|regulation of growth|
|gamete generation|
|regulation of cytokine production|
|positive regulation of cell death|
|viral process|
|regulated exocytosis|
|negative regulation of cellular component organization|
|regulation of proteolysis|
|protein localization to organelle|
|regulation of cell cycle process|
|organelle assembly|
|innate immune response|
|leukocyte mediated immunity|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|symbiotic process|
|cellular amide metabolic process|
|negative regulation of catalytic activity|
|exocytosis|
|regulation of protein kinase activity|
|interspecies interaction between organisms|
|multicellular organismal reproductive process|
|sexual reproduction|
|cellular protein-containing complex assembly|
|multicellular organism reproduction|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|apoptotic process|
|leukocyte activation|
|defense response to other organism|
|regulation of cellular component biogenesis|
|regulation of transferase activity|
|multi-organism reproductive process|
|negative regulation of cell death|
|secretion by cell|
|positive regulation of protein phosphorylation|
|negative regulation of cellular protein metabolic process|
|export from cell|
|programmed cell death|
|positive regulation of phosphorylation|
|chromosome organization|
|cell activation|
|cell death|
|immune effector process|
|negative regulation of protein metabolic process|
|cell-cell signaling|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|response to abiotic stimulus|
|regulation of cell cycle|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|RNA metabolic process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-3.85|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-3.78|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-3.35|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-3.18|
|[[:results:exp17|DABN 20μM R00 exp17]]|-3.09|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-3.05|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-2.64|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.57|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-2.55|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-2.5|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-2.49|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-2.48|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-2.42|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-2.4|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.4|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-2.37|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-2.37|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-2.21|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-2.19|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-2.18|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-2.18|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-2.17|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|-2.17|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-2.12|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|-2.01|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-2|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-1.99|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-1.98|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.9|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-1.89|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-1.86|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-1.85|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.84|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-1.83|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|-1.82|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-1.74|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.7|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|1.7|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.77|
|[[:results:exp519|RS-1 10μM R08 exp519]]|1.8|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.81|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|1.82|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.82|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|1.93|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|2.04|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|2.05|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|2.1|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|2.2|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.27|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|2.34|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|2.37|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|2.38|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.44|
|[[:results:exp274|Citral 50μM R06 exp274]]|2.53|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|2.55|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|2.62|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.63|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|2.77|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.8|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|3.1|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|3.21|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|3.27|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|3.39|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|3.5|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|3.52|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|3.62|
|[[:results:exp210|LB-100 2μM R05 exp210]]|3.64|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|3.68|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|3.82|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|3.97|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|4.2|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|4.91|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|5.2|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|6.48|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|7.12|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.524|
|[[:human genes:p:ptma|PTMA]]|0.516|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.512|
|[[:human genes:e:eif4b|EIF4B]]|0.494|
|[[:human genes:e:eif4h|EIF4H]]|0.455|
|[[:human genes:p:pds5a|PDS5A]]|0.446|
|[[:human genes:z:zbtb7a|ZBTB7A]]|0.44|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.439|
|[[:human genes:e:eif3g|EIF3G]]|0.434|
|[[:human genes:m:myb|MYB]]|0.429|
|[[:human genes:p:psmb4|PSMB4]]|0.428|
|[[:human genes:n:nelfa|NELFA]]|0.411|
|[[:human genes:p:prpf3|PRPF3]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 513/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|21/28|
|blood|13/26|
|bone|15/26|
|breast|27/30|
|central nervous system|27/49|
|cervix|4/4|
|colorectal|16/17|
|esophagus|11/11|
|fibroblast|0/1|
|gastric|12/14|
|kidney|11/18|
|liver|11/19|
|lung|55/72|
|lymphocyte|6/16|
|ovary|25/25|
|pancreas|17/22|
|peripheral nervous system|9/15|
|plasma cell|10/12|
|prostate|0/1|
|skin|10/20|
|soft tissue|7/9|
|thyroid|2/2|
|upper aerodigestive|14/22|
|urinary tract|24/28|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 19075
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.76 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DDX3X Expression in NALM6 Cells: 8.76'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>