DDX42 [The Human Chemical-Genetic Interaction Map Project]

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======= DDX42 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DDX42
  * **<color #00a2e8>Official Name</color>**: DEAD-box helicase 42
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11325|11325]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86XP3|Q86XP3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DDX42&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DDX42|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613369|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  ATP-dependent RNA helicase. Binds to partially double- stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2. Relocalizes TP53BP2 to the cytoplasm. {ECO:0000269|PubMed:16397294, ECO:0000269|PubMed:19377511}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DEAD|
|Helicase C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Cajal body|
|RNA helicase activity|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|nuclear speck|
|mRNA processing|
|mRNA metabolic process|
|RNA processing|
|RNA binding|
|ATP binding|
|regulation of apoptotic process|
|regulation of programmed cell death|
|RNA metabolic process|
|regulation of cell death|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-1.83|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.79|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.05|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|2.36|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|2.47|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|2.58|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:ppp6c|PPP6C]]|0.5|
|[[:human genes:t:tubd1|TUBD1]]|0.467|
|[[:human genes:p:pik3c3|PIK3C3]]|0.429|
|[[:human genes:b:bak1|BAK1]]|0.426|
|[[:human genes:c:c14orf80|C14orf80]]|0.424|
|[[:human genes:s:srp14|SRP14]]|0.424|
|[[:human genes:f:faf2|FAF2]]|0.423|
|[[:human genes:c:c16orf59|C16orf59]]|0.413|
|[[:human genes:t:trim28|TRIM28]]|0.412|
|[[:human genes:p:pfn1|PFN1]]|0.408|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 593/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|20/28|
|blood|19/28|
|bone|20/26|
|breast|28/33|
|central nervous system|43/56|
|cervix|1/4|
|colorectal|15/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|13/16|
|kidney|19/21|
|liver|17/20|
|lung|57/75|
|lymphocyte|12/16|
|ovary|21/26|
|pancreas|20/24|
|peripheral nervous system|12/16|
|plasma cell|10/15|
|prostate|1/1|
|skin|21/24|
|soft tissue|8/9|
|thyroid|1/2|
|upper aerodigestive|19/22|
|urinary tract|26/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1984
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.1 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DDX42 Expression in NALM6 Cells: 8.1'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>