DDX55 [The Human Chemical-Genetic Interaction Map Project]

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======= DDX55 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DDX55
  * **<color #00a2e8>Official Name</color>**: DEAD-box helicase 55
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57696|57696]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NHQ9|Q8NHQ9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DDX55&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DDX55|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620176|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Probable ATP-binding RNA helicase.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Helicase C|
|DEAD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA helicase activity|
|nucleolus|
|RNA binding|
|ATP binding|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|-2.25|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-2.22|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|-2.13|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-2.13|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-2.1|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|-2.07|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-2.05|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-2.02|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|-1.98|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-1.93|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-1.9|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-1.89|
|[[:results:exp148|SB202190 10μM R03 exp148]]|-1.88|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-1.85|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|-1.8|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|-1.79|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|-1.79|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|-1.78|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|-1.77|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|-1.75|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-1.71|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-1.71|
|[[:results:exp100|NFN1 1μM R03 exp100]]|-1.71|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|2.07|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|2.16|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|2.19|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|2.2|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.34|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.58|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.67|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:u:utp23|UTP23]]|0.557|
|[[:human genes:t:thg1l|THG1L]]|0.549|
|[[:human genes:g:gemin8|GEMIN8]]|0.511|
|[[:human genes:r:rtcb|RTCB]]|0.511|
|[[:human genes:a:alg1|ALG1]]|0.508|
|[[:human genes:t:triap1|TRIAP1]]|0.497|
|[[:human genes:h:hars|HARS]]|0.493|
|[[:human genes:t:ten1|TEN1]]|0.483|
|[[:human genes:d:ddx20|DDX20]]|0.483|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.475|
|[[:human genes:o:oip5|OIP5]]|0.474|
|[[:human genes:g:gfpt1|GFPT1]]|0.473|
|[[:human genes:g:gmppb|GMPPB]]|0.473|
|[[:human genes:p:pmm2|PMM2]]|0.47|
|[[:human genes:c:ctc1|CTC1]]|0.469|
|[[:human genes:r:rpp21|RPP21]]|0.469|
|[[:human genes:r:rnmt|RNMT]]|0.462|
|[[:human genes:t:tbca|TBCA]]|0.459|
|[[:human genes:u:uap1|UAP1]]|0.457|
|[[:human genes:h:haus8|HAUS8]]|0.455|
|[[:human genes:a:alg13|ALG13]]|0.454|
|[[:human genes:g:gemin6|GEMIN6]]|0.453|
|[[:human genes:g:gemin7|GEMIN7]]|0.451|
|[[:human genes:t:tamm41|TAMM41]]|0.451|
|[[:human genes:a:adsl|ADSL]]|0.449|
|[[:human genes:t:tbcb|TBCB]]|0.449|
|[[:human genes:n:nae1|NAE1]]|0.443|
|[[:human genes:s:srp14|SRP14]]|0.443|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.438|
|[[:human genes:r:rptor|RPTOR]]|0.437|
|[[:human genes:e:eno1|ENO1]]|0.437|
|[[:human genes:d:dpagt1|DPAGT1]]|0.436|
|[[:human genes:k:kdm8|KDM8]]|0.434|
|[[:human genes:r:rpe|RPE]]|0.431|
|[[:human genes:t:tgs1|TGS1]]|0.428|
|[[:human genes:e:exoc4|EXOC4]]|0.423|
|[[:human genes:m:mis18a|MIS18A]]|0.421|
|[[:human genes:c:c15orf41|C15orf41]]|0.42|
|[[:human genes:u:uhrf1|UHRF1]]|0.419|
|[[:human genes:y:yars|YARS]]|0.419|
|[[:human genes:r:rabggtb|RABGGTB]]|0.418|
|[[:human genes:g:gemin5|GEMIN5]]|0.417|
|[[:human genes:d:dr1|DR1]]|0.415|
|[[:human genes:v:vezt|VEZT]]|0.412|
|[[:human genes:d:dhps|DHPS]]|0.411|
|[[:human genes:p:ppcs|PPCS]]|0.411|
|[[:human genes:e:eif4e|EIF4E]]|0.408|
|[[:human genes:t:trnt1|TRNT1]]|0.408|
|[[:human genes:s:sgol1|SGOL1]]|0.407|
|[[:human genes:m:mars|MARS]]|0.406|
|[[:human genes:r:rft1|RFT1]]|0.404|
|[[:human genes:w:wdr1|WDR1]]|0.404|
|[[:human genes:t:tsen54|TSEN54]]|0.403|
|[[:human genes:s:srpk1|SRPK1]]|0.403|
|[[:human genes:d:dpf2|DPF2]]|0.401|
|[[:human genes:q:qars|QARS]]|0.401|
|[[:human genes:a:atxn10|ATXN10]]|0.401|
|[[:human genes:t:txnl4b|TXNL4B]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 732/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|32/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|19/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1849
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DDX55 Expression in NALM6 Cells: 6.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>