DERL1 [The Human Chemical-Genetic Interaction Map Project]

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======= DERL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DERL1
  * **<color #00a2e8>Official Name</color>**: derlin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79139|79139]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BUN8|Q9BUN8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DERL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DERL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608813|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the misfolded protein (PubMed:15215856). Also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). {ECO:0000269|PubMed:15215856, ECO:0000269|PubMed:26565908}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DER1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Derlin-1-VIMP complex|
|signal recognition particle receptor complex|
|signal recognition particle|
|Hrd1p ubiquitin ligase ERAD-L complex|
|Derlin-1 retrotranslocation complex|
|ER-associated misfolded protein catabolic process|
|ubiquitin-specific protease binding|
|endoplasmic reticulum to cytosol transport|
|retrograde protein transport, ER to cytosol|
|MHC class I protein binding|
|cellular response to misfolded protein|
|protein exit from endoplasmic reticulum|
|misfolded protein binding|
|response to misfolded protein|
|protein quality control for misfolded or incompletely synthesized proteins|
|protein destabilization|
|ubiquitin-dependent ERAD pathway|
|ATPase binding|
|ERAD pathway|
|positive regulation of protein binding|
|protease binding|
|endoplasmic reticulum unfolded protein response|
|integral component of endoplasmic reticulum membrane|
|positive regulation of protein ubiquitination|
|late endosome|
|cellular response to unfolded protein|
|positive regulation of protein modification by small protein conjugation or removal|
|cellular response to topologically incorrect protein|
|response to unfolded protein|
|positive regulation of binding|
|response to topologically incorrect protein|
|regulation of protein ubiquitination|
|signaling receptor activity|
|regulation of protein binding|
|regulation of protein modification by small protein conjugation or removal|
|protein folding|
|early endosome|
|response to endoplasmic reticulum stress|
|regulation of protein stability|
|ubiquitin protein ligase binding|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|protein homooligomerization|
|proteasomal protein catabolic process|
|regulation of binding|
|protein complex oligomerization|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|protein ubiquitination|
|viral process|
|protein modification by small protein conjugation|
|symbiotic process|
|interspecies interaction between organisms|
|cellular macromolecule catabolic process|
|endoplasmic reticulum membrane|
|protein modification by small protein conjugation or removal|
|intracellular protein transport|
|response to organonitrogen compound|
|endoplasmic reticulum|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|positive regulation of protein modification process|
|proteolysis|
|transmembrane transport|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|cellular response to stress|
|positive regulation of protein metabolic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-4.12|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-3.37|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.79|
|[[:results:exp359|FK-506 30μM R07 exp359]]|-2.71|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-2.68|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-2.62|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.45|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-2.44|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-2.43|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-2.31|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|-2.27|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-2.22|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|-2.01|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-1.96|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-1.93|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-1.9|
|[[:results:exp219|A-395N 10μM R05 exp219]]|-1.83|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|-1.81|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-1.79|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|-1.72|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|-1.71|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|1.82|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|1.84|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|1.97|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|2.14|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.23|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dnajc3|DNAJC3]]|0.579|
|[[:human genes:a:alg5|ALG5]]|0.529|
|[[:human genes:m:manf|MANF]]|0.528|
|[[:human genes:u:ube2j1|UBE2J1]]|0.505|
|[[:human genes:d:derl2|DERL2]]|0.492|
|[[:human genes:g:gtf2i|GTF2I]]|0.48|
|[[:human genes:d:dnajb11|DNAJB11]]|0.473|
|[[:human genes:u:ufm1|UFM1]]|0.464|
|[[:human genes:a:alg9|ALG9]]|0.463|
|[[:human genes:t:tmed10|TMED10]]|0.45|
|[[:human genes:u:ube2g2|UBE2G2]]|0.45|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.433|
|[[:human genes:e:eny2|ENY2]]|0.427|
|[[:human genes:s:slc33a1|SLC33A1]]|0.425|
|[[:human genes:x:xpo6|XPO6]]|0.422|
|[[:human genes:c:c1orf27|C1orf27]]|0.415|
|[[:human genes:u:uba5|UBA5]]|0.413|
|[[:human genes:r:rnmt|RNMT]]|0.412|
|[[:human genes:b:bcl2|BCL2]]|0.409|
|[[:human genes:n:nxt1|NXT1]]|0.406|
|[[:human genes:d:dpagt1|DPAGT1]]|0.404|
|[[:human genes:r:rer1|RER1]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|1/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8086
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DERL1 Expression in NALM6 Cells: 6.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>