DGAT2 [The Human Chemical-Genetic Interaction Map Project]

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======= DGAT2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DGAT2
  * **<color #00a2e8>Official Name</color>**: diacylglycerol O-acyltransferase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84649|84649]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96PD7|Q96PD7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DGAT2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DGAT2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606983|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which diacylglycerol is covalently bound to long chain fatty acyl-CoAs. The encoded protein catalyzes this reaction at low concentrations of magnesium chloride while the other enzyme has high activity at high concentrations of magnesium chloride. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Functions also as an acyl-CoA retinol acyltransferase (ARAT). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DAGAT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|retinol O-fatty-acyltransferase activity|
|cellular response to oleic acid|
|diacylglycerol O-acyltransferase activity|
|perinuclear endoplasmic reticulum membrane|
|2-acylglycerol O-acyltransferase activity|
|response to oleic acid|
|cellular triglyceride homeostasis|
|fat pad development|
|acylglycerol acyl-chain remodeling|
|negative regulation of fatty acid oxidation|
|positive regulation of triglyceride biosynthetic process|
|regulation of lipoprotein metabolic process|
|positive regulation of gluconeogenesis|
|fatty acid homeostasis|
|regulation of triglyceride biosynthetic process|
|positive regulation of triglyceride metabolic process|
|triglyceride biosynthetic process|
|glycerol metabolic process|
|acylglycerol biosynthetic process|
|diacylglycerol metabolic process|
|neutral lipid biosynthetic process|
|low-density lipoprotein particle clearance|
|alditol metabolic process|
|negative regulation of fatty acid metabolic process|
|long-chain fatty-acyl-CoA metabolic process|
|lipid storage|
|regulation of fatty acid oxidation|
|regulation of triglyceride metabolic process|
|triglyceride homeostasis|
|acylglycerol homeostasis|
|adipose tissue development|
|positive regulation of glucose metabolic process|
|plasma lipoprotein particle clearance|
|fatty-acyl-CoA metabolic process|
|retinol metabolic process|
|regulation of gluconeogenesis|
|cellular response to fatty acid|
|regulation of cholesterol metabolic process|
|anion homeostasis|
|positive regulation of cellular carbohydrate metabolic process|
|regulation of plasma lipoprotein particle levels|
|triglyceride metabolic process|
|primary alcohol metabolic process|
|cholesterol homeostasis|
|positive regulation of carbohydrate metabolic process|
|positive regulation of lipid biosynthetic process|
|sterol homeostasis|
|lipid droplet|
|negative regulation of lipid metabolic process|
|response to fatty acid|
|regulation of fatty acid metabolic process|
|negative regulation of small molecule metabolic process|
|regulation of carbohydrate biosynthetic process|
|acyl-CoA metabolic process|
|thioester metabolic process|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|retinoid metabolic process|
|integral component of endoplasmic reticulum membrane|
|diterpenoid metabolic process|
|polyol metabolic process|
|regulation of glucose metabolic process|
|regulation of steroid metabolic process|
|terpenoid metabolic process|
|cellular hormone metabolic process|
|ribonucleoside bisphosphate metabolic process|
|nucleoside bisphosphate metabolic process|
|purine nucleoside bisphosphate metabolic process|
|lipid homeostasis|
|positive regulation of small molecule metabolic process|
|isoprenoid metabolic process|
|regulation of cellular carbohydrate metabolic process|
|positive regulation of lipid metabolic process|
|maintenance of location|
|fatty acid derivative metabolic process|
|cellular carbohydrate metabolic process|
|regulation of cellular ketone metabolic process|
|regulation of lipid biosynthetic process|
|hormone metabolic process|
|regulation of carbohydrate metabolic process|
|cellular response to acid chemical|
|glycerolipid biosynthetic process|
|connective tissue development|
|coenzyme metabolic process|
|purine ribonucleotide metabolic process|
|alcohol metabolic process|
|lipid localization|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|response to acid chemical|
|sulfur compound metabolic process|
|purine-containing compound metabolic process|
|glycerolipid metabolic process|
|regulation of lipid metabolic process|
|regulation of small molecule metabolic process|
|cofactor metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic hydroxy compound metabolic process|
|carbohydrate metabolic process|
|cellular response to lipid|
|regulation of hormone levels|
|nucleobase-containing small molecule metabolic process|
|lipid biosynthetic process|
|perinuclear region of cytoplasm|
|cellular chemical homeostasis|
|cellular amide metabolic process|
|ion homeostasis|
|response to lipid|
|protein homodimerization activity|
|organophosphate metabolic process|
|cellular homeostasis|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|endoplasmic reticulum|
|carbohydrate derivative metabolic process|
|cellular response to oxygen-containing compound|
|chemical homeostasis|
|lipid metabolic process|
|mitochondrion|
|response to oxygen-containing compound|
|homeostatic process|
|small molecule metabolic process|
|tissue development|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|1.76|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|2.2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8409
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DGAT2 Expression in NALM6 Cells: 3.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>