DHX15 [The Human Chemical-Genetic Interaction Map Project]

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======= DHX15 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DHX15
  * **<color #00a2e8>Official Name</color>**: DEAH-box helicase 15
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1665|1665]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43143|O43143]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DHX15&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DHX15|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603403|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. {ECO:0000269|PubMed:19103666}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|OB NTP bind|
|DEAD|
|HA2|
|Helicase C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|U2-type post-mRNA release spliceosomal complex|
|3-5 RNA helicase activity|
|U12-type spliceosomal complex|
|RNA helicase activity|
|double-stranded RNA binding|
|response to alkaloid|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|nuclear speck|
|mRNA processing|
|response to toxic substance|
|mRNA metabolic process|
|nucleolus|
|RNA processing|
|response to organonitrogen compound|
|response to nitrogen compound|
|RNA binding|
|ATP binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.48|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.98|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-1.73|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.74|
|[[:results:exp496|Lead acetate 990μM R08 exp496]]|1.76|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.84|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|1.84|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|1.86|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|1.91|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|1.96|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|1.97|
|[[:results:exp114|A-196 10μM R03 exp114]]|1.98|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|2.47|
|[[:results:exp274|Citral 50μM R06 exp274]]|2.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:ruvbl2|RUVBL2]]|0.493|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 711/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|27/28|
|bone|25/26|
|breast|30/33|
|central nervous system|53/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|20/21|
|liver|20/20|
|lung|72/75|
|lymphocyte|16/16|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|13/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 326
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.85 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DHX15 Expression in NALM6 Cells: 8.85'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>