DHX29 [The Human Chemical-Genetic Interaction Map Project]

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======= DHX29 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DHX29
  * **<color #00a2e8>Official Name</color>**: DExH-box helicase 29
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54505|54505]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z478|Q7Z478]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DHX29&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DHX29|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612720|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein functions in translation initiation, and is specifically required for ribosomal scanning across stable mRNA secondary structures during initiation codon selection. This protein may also play a role in sensing virally derived cytosolic nucleic acids. Knockdown of this gene results in reduced protein translation and impaired proliferation of cancer cells. [provided by RefSeq, Sep 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity. {ECO:0000255|HAMAP-Rule:MF_03068, ECO:0000269|PubMed:19109895, ECO:0000269|PubMed:23706745}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Helicase C|
|OB NTP bind|
|DEAD|
|HA2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ribosomal small subunit binding|
|eukaryotic 43S preinitiation complex|
|3-5 RNA helicase activity|
|positive regulation of translational initiation|
|translation initiation factor activity|
|regulation of translational initiation|
|positive regulation of translation|
|translational initiation|
|positive regulation of cellular amide metabolic process|
|cadherin binding|
|regulation of translation|
|translation|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|ATP binding|
|positive regulation of cellular protein metabolic process|
|cellular nitrogen compound biosynthetic process|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-2.69|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-1.97|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-1.8|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.8|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.82|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.85|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|1.88|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|3.49|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mllt1|MLLT1]]|0.558|
|[[:human genes:r:rtcb|RTCB]]|0.486|
|[[:human genes:a:atf7ip|ATF7IP]]|0.486|
|[[:human genes:c:ccdc101|CCDC101]]|0.474|
|[[:human genes:a:alg13|ALG13]]|0.465|
|[[:human genes:d:dpf2|DPF2]]|0.463|
|[[:human genes:a:aars|AARS]]|0.46|
|[[:human genes:g:gnb1l|GNB1L]]|0.458|
|[[:human genes:t:thoc6|THOC6]]|0.454|
|[[:human genes:r:rnmt|RNMT]]|0.454|
|[[:human genes:r:rptor|RPTOR]]|0.452|
|[[:human genes:h:hars|HARS]]|0.448|
|[[:human genes:d:dpagt1|DPAGT1]]|0.445|
|[[:human genes:m:med16|MED16]]|0.436|
|[[:human genes:n:nars|NARS]]|0.431|
|[[:human genes:u:uap1|UAP1]]|0.43|
|[[:human genes:c:cbfb|CBFB]]|0.429|
|[[:human genes:p:pmm2|PMM2]]|0.428|
|[[:human genes:u:uhrf1|UHRF1]]|0.428|
|[[:human genes:d:dnajc3|DNAJC3]]|0.427|
|[[:human genes:f:fli1|FLI1]]|0.427|
|[[:human genes:n:nsd1|NSD1]]|0.424|
|[[:human genes:o:otud5|OTUD5]]|0.422|
|[[:human genes:g:gmppb|GMPPB]]|0.418|
|[[:human genes:g:gfpt1|GFPT1]]|0.413|
|[[:human genes:z:zfx|ZFX]]|0.412|
|[[:human genes:t:tti2|TTI2]]|0.412|
|[[:human genes:y:yars|YARS]]|0.411|
|[[:human genes:c:cbx3|CBX3]]|0.41|
|[[:human genes:a:atp5j|ATP5J]]|0.409|
|[[:human genes:x:xpo6|XPO6]]|0.409|
|[[:human genes:t:trmt5|TRMT5]]|0.408|
|[[:human genes:t:triap1|TRIAP1]]|0.402|
|[[:human genes:m:med23|MED23]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 11/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2705
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DHX29 Expression in NALM6 Cells: 5.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>