DIS3 [The Human Chemical-Genetic Interaction Map Project]

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======= DIS3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DIS3
  * **<color #00a2e8>Official Name</color>**: DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22894|22894]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y2L1|Q9Y2L1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DIS3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DIS3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607533|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RNB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CUT metabolic process|
|CUT catabolic process|
|cytoplasmic exosome (RNase complex)|
|nuclear exosome (RNase complex)|
|exosome (RNase complex)|
|rRNA catabolic process|
|ncRNA catabolic process|
|3-5-exoribonuclease activity|
|exonucleolytic catabolism of deadenylated mRNA|
|nuclear-transcribed mRNA catabolic process, exonucleolytic|
|endonuclease activity|
|RNA phosphodiester bond hydrolysis, exonucleolytic|
|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|guanyl-nucleotide exchange factor activity|
|RNA phosphodiester bond hydrolysis|
|regulation of mRNA stability|
|regulation of RNA stability|
|nuclear-transcribed mRNA catabolic process|
|regulation of mRNA catabolic process|
|rRNA processing|
|mRNA catabolic process|
|rRNA metabolic process|
|RNA catabolic process|
|nucleic acid phosphodiester bond hydrolysis|
|ribosome biogenesis|
|regulation of mRNA metabolic process|
|nucleobase-containing compound catabolic process|
|ncRNA processing|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|organic cyclic compound catabolic process|
|posttranscriptional regulation of gene expression|
|mRNA metabolic process|
|regulation of cellular catabolic process|
|nucleolus|
|RNA processing|
|cellular macromolecule catabolic process|
|regulation of catabolic process|
|macromolecule catabolic process|
|RNA binding|
|RNA metabolic process|
|negative regulation of gene expression|
|organic substance catabolic process|
|cellular catabolic process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 257/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|10/28|
|blood|8/28|
|bone|5/26|
|breast|12/33|
|central nervous system|16/56|
|cervix|0/4|
|colorectal|3/17|
|esophagus|6/13|
|fibroblast|0/1|
|gastric|5/16|
|kidney|9/21|
|liver|6/20|
|lung|33/75|
|lymphocyte|6/16|
|ovary|7/26|
|pancreas|8/24|
|peripheral nervous system|5/16|
|plasma cell|6/15|
|prostate|1/1|
|skin|5/24|
|soft tissue|5/9|
|thyroid|1/2|
|upper aerodigestive|9/22|
|urinary tract|9/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1104
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DIS3 Expression in NALM6 Cells: 7.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>