DISP1 [The Human Chemical-Genetic Interaction Map Project]

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======= DISP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DISP1
  * **<color #00a2e8>Official Name</color>**: dispatched RND transporter family member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84976|84976]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96F81|Q96F81]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DISP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DISP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607502|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (By similarity). Synergizes with SCUBE2 to cause a increase in SHH secretion (PubMed:22902404). {ECO:0000250|UniProtKB:Q3TDN0, ECO:0000269|PubMed:22902404}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Patched|
|MMPL|
|Sterol-sensing|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|patched ligand maturation|
|signal maturation|
|diaphragm development|
|peptide transmembrane transporter activity|
|positive regulation of smoothened signaling pathway|
|protein homotrimerization|
|protein trimerization|
|embryonic pattern specification|
|regulation of smoothened signaling pathway|
|dorsal/ventral pattern formation|
|determination of left/right symmetry|
|determination of bilateral symmetry|
|specification of symmetry|
|skeletal muscle organ development|
|respiratory system development|
|basolateral plasma membrane|
|protein maturation|
|muscle organ development|
|regionalization|
|protein homooligomerization|
|pattern specification process|
|regulation of protein secretion|
|muscle structure development|
|regulation of peptide secretion|
|protein complex oligomerization|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|embryo development|
|regulation of protein localization|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|positive regulation of signal transduction|
|positive regulation of cell communication|
|positive regulation of signaling|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp480|ETC-159 50μM R08 exp480]]|1.77|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.8|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|2.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15198
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DISP1 Expression in NALM6 Cells: 2.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>