DLG4 [The Human Chemical-Genetic Interaction Map Project]

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======= DLG4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DLG4
  * **<color #00a2e8>Official Name</color>**: discs large MAGUK scaffold protein 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1742|1742]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P78352|P78352]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DLG4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DLG4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602887|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH3 2|
|PDZ|
|Guanylate kin|
|SH3 1|
|PDZ assoc|
|MAGUK N PEST|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|P2Y1 nucleotide receptor binding|
|AMPA glutamate receptor clustering|
|glutamate receptor clustering|
|beta-1 adrenergic receptor binding|
|regulation of grooming behavior|
|neuroligin family protein binding|
|cerebellar mossy fiber|
|neuron spine|
|positive regulation of neuron projection arborization|
|neurotransmitter-gated ion channel clustering|
|neurotransmitter receptor diffusion trapping|
|postsynaptic neurotransmitter receptor diffusion trapping|
|D1 dopamine receptor binding|
|receptor diffusion trapping|
|regulation of neuron projection arborization|
|cellular response to potassium ion|
|juxtaparanode region of axon|
|synaptic vesicle maturation|
|negative regulation of receptor internalization|
|neurotransmitter receptor localization to postsynaptic specialization membrane|
|protein localization to postsynaptic specialization membrane|
|ionotropic glutamate receptor complex|
|locomotory exploration behavior|
|acetylcholine receptor binding|
|response to potassium ion|
|dendritic spine morphogenesis|
|vocalization behavior|
|cortical cytoskeleton|
|neuron projection terminus|
|negative regulation of receptor-mediated endocytosis|
|postsynaptic density membrane|
|exploration behavior|
|synaptic membrane|
|AMPA glutamate receptor complex|
|regulation of long-term neuronal synaptic plasticity|
|positive regulation of excitatory postsynaptic potential|
|postsynaptic membrane organization|
|dendritic spine development|
|dendrite cytoplasm|
|dendritic spine organization|
|excitatory synapse|
|ionotropic glutamate receptor binding|
|protein localization to postsynaptic membrane|
|regulation of NMDA receptor activity|
|modulation of excitatory postsynaptic potential|
|neuron projection organization|
|receptor localization to synapse|
|negative regulation of endocytosis|
|receptor clustering|
|regulation of postsynaptic membrane neurotransmitter receptor levels|
|neuromuscular process controlling balance|
|intraspecies interaction between organisms|
|social behavior|
|regulation of neuronal synaptic plasticity|
|regulation of receptor internalization|
|positive regulation of protein tyrosine kinase activity|
|dendrite morphogenesis|
|scaffold protein binding|
|extrinsic component of cytoplasmic side of plasma membrane|
|positive regulation of nervous system process|
|protein localization to synapse|
|regulation of glutamate receptor signaling pathway|
|multi-organism behavior|
|endocytic vesicle membrane|
|regulation of behavior|
|regulation of neurotransmitter receptor activity|
|neuromuscular junction|
|voltage-gated potassium channel complex|
|localization within membrane|
|protein phosphatase binding|
|postsynapse organization|
|PDZ domain binding|
|regulation of protein tyrosine kinase activity|
|kinase binding|
|regulation of receptor-mediated endocytosis|
|dendrite development|
|neuromuscular process|
|synaptic vesicle|
|regulation of nervous system process|
|learning|
|dendritic spine|
|positive regulation of synaptic transmission|
|regulation of cation channel activity|
|regulation of signaling receptor activity|
|protein C-terminus binding|
|regulation of synaptic plasticity|
|positive regulation of peptidyl-tyrosine phosphorylation|
|cellular response to metal ion|
|locomotory behavior|
|postsynaptic membrane|
|regulation of endocytosis|
|cellular response to inorganic substance|
|protein localization to cell periphery|
|developmental maturation|
|postsynaptic density|
|regulation of peptidyl-tyrosine phosphorylation|
|protein-containing complex localization|
|regulation of ion transmembrane transporter activity|
|learning or memory|
|regulation of transmembrane transporter activity|
|protein-containing complex binding|
|synapse|
|synapse organization|
|regulation of transporter activity|
|positive regulation of neuron projection development|
|positive regulation of cytosolic calcium ion concentration|
|cognition|
|vesicle organization|
|neuron projection|
|regulation of cytosolic calcium ion concentration|
|regulation of cation transmembrane transport|
|glutamatergic synapse|
|positive regulation of neuron differentiation|
|response to metal ion|
|MAPK cascade|
|positive regulation of cell projection organization|
|signal transduction by protein phosphorylation|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|regulation of membrane potential|
|cell morphogenesis involved in neuron differentiation|
|cellular calcium ion homeostasis|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|calcium ion homeostasis|
|synaptic signaling|
|cellular divalent inorganic cation homeostasis|
|positive regulation of neurogenesis|
|regulation of ion transmembrane transport|
|neuron projection morphogenesis|
|protein localization to membrane|
|plasma membrane bounded cell projection morphogenesis|
|negative regulation of transport|
|divalent inorganic cation homeostasis|
|cell projection morphogenesis|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|cell-cell adhesion|
|cell part morphogenesis|
|response to inorganic substance|
|positive regulation of protein kinase activity|
|positive regulation of nervous system development|
|positive regulation of cell development|
|cell junction|
|regulation of vesicle-mediated transport|
|cell morphogenesis involved in differentiation|
|cellular metal ion homeostasis|
|regulation of transmembrane transport|
|behavior|
|positive regulation of kinase activity|
|regulation of system process|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|positive regulation of transferase activity|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of plasma membrane bounded cell projection organization|
|regulation of ion transport|
|negative regulation of cellular component organization|
|cation homeostasis|
|regulation of cell projection organization|
|inorganic ion homeostasis|
|cell morphogenesis|
|protein localization to organelle|
|cellular chemical homeostasis|
|ion homeostasis|
|regulation of protein kinase activity|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|membrane organization|
|regulation of kinase activity|
|cellular homeostasis|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of transferase activity|
|neuron differentiation|
|endoplasmic reticulum|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|chemical homeostasis|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|cell projection organization|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|phosphorylation|
|positive regulation of developmental process|
|nervous system process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|generation of neurons|
|protein-containing complex assembly|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|neurogenesis|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp302|35°C R06 exp302]]|-1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3478
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DLG4 Expression in NALM6 Cells: 4.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>