DLX1 [The Human Chemical-Genetic Interaction Map Project]

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======= DLX1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DLX1
  * **<color #00a2e8>Official Name</color>**: distal-less homeobox 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1745|1745]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P56177|P56177]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DLX1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DLX1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600029|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein is localized to the nucleus where it may function as a transcriptional regulator of signals from multiple TGF-{beta} superfamily members. The encoded protein may play a role in the control of craniofacial patterning and the differentiation and survival of inhibitory neurons in the forebrain. This gene is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 2. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role as a transcriptional activator or repressor (PubMed:14671321). Inhibits several cytokine signaling pathways, such as TGFB1, activin-A/INHBA and BMP4 by interfering with the transcriptional stimulatory activity of transcription factors, such as MSX2, FAST2, SMAD2 and SMAD3 during hematopoietic cell differentiation (PubMed:14671321). Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina (By similarity). Likely to play a regulatory role in the development of the ventral forebrain (By similarity). May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions (By similarity). {ECO:0000250|UniProtKB:Q64317, ECO:0000269|PubMed:14671321}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Homeobox|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of retina development in camera-type eye|
|cerebral cortex GABAergic interneuron fate commitment|
|regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment|
|commitment of multipotent stem cells to neuronal lineage in forebrain|
|positive regulation of amacrine cell differentiation|
|positive regulation of neural retina development|
|regulation of amacrine cell differentiation|
|regulation of neural retina development|
|regulation of retina development in camera-type eye|
|negative regulation of photoreceptor cell differentiation|
|regulation of photoreceptor cell differentiation|
|forebrain neuron fate commitment|
|cerebral cortex GABAergic interneuron differentiation|
|negative regulation of oligodendrocyte differentiation|
|GABAergic neuron differentiation|
|regulation of transcription involved in cell fate commitment|
|cerebral cortex neuron differentiation|
|subpallium development|
|negative regulation of glial cell differentiation|
|proximal/distal pattern formation|
|regulation of oligodendrocyte differentiation|
|negative regulation of gliogenesis|
|negative regulation of Notch signaling pathway|
|negative regulation of BMP signaling pathway|
|forebrain neuron differentiation|
|neuron fate commitment|
|forebrain generation of neurons|
|regulation of glial cell differentiation|
|negative regulation of cellular response to transforming growth factor beta stimulus|
|hippocampus development|
|odontogenesis of dentin-containing tooth|
|regulation of BMP signaling pathway|
|regulation of Notch signaling pathway|
|response to BMP|
|cellular response to BMP stimulus|
|limbic system development|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of cellular response to transforming growth factor beta stimulus|
|regulation of gliogenesis|
|odontogenesis|
|embryonic skeletal system development|
|negative regulation of neuron apoptotic process|
|negative regulation of cellular response to growth factor stimulus|
|cellular response to transforming growth factor beta stimulus|
|response to transforming growth factor beta|
|pallium development|
|central nervous system neuron differentiation|
|negative regulation of neuron death|
|regulation of neuron apoptotic process|
|negative regulation of neuron differentiation|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|cell fate commitment|
|telencephalon development|
|regulation of cellular response to growth factor stimulus|
|negative regulation of neurogenesis|
|regulation of neuron death|
|negative regulation of nervous system development|
|regionalization|
|negative regulation of cell development|
|positive regulation of neuron differentiation|
|forebrain development|
|chromatin binding|
|sequence-specific DNA binding|
|pattern specification process|
|positive regulation of neurogenesis|
|skeletal system development|
|cellular response to growth factor stimulus|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|response to growth factor|
|positive regulation of nervous system development|
|positive regulation of cell development|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|regulation of neuron differentiation|
|DNA-binding transcription factor activity|
|negative regulation of cell differentiation|
|brain development|
|head development|
|regulation of neurogenesis|
|negative regulation of transcription by RNA polymerase II|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|embryo development|
|central nervous system development|
|negative regulation of cell death|
|neuron differentiation|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of cell death|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12495
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DLX1 Expression in NALM6 Cells: 0.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>