DLX5 [The Human Chemical-Genetic Interaction Map Project]

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======= DLX5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DLX5
  * **<color #00a2e8>Official Name</color>**: distal-less homeobox 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1749|1749]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P56178|P56178]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DLX5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DLX5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600028|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein may play a role in bone development and fracture healing. Mutation in this gene, which is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7, may be associated with split-hand/split-foot malformation. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding. {ECO:0000269|PubMed:19497851}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DLL N|
|Homeobox|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|olfactory pit development|
|interneuron axon guidance|
|olfactory bulb interneuron differentiation|
|nose development|
|HMG box domain binding|
|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|
|endochondral ossification|
|replacement ossification|
|olfactory bulb development|
|face morphogenesis|
|olfactory lobe development|
|head morphogenesis|
|body morphogenesis|
|face development|
|forebrain neuron differentiation|
|forebrain generation of neurons|
|endochondral bone morphogenesis|
|BMP signaling pathway|
|roof of mouth development|
|inner ear morphogenesis|
|response to BMP|
|cellular response to BMP stimulus|
|bone morphogenesis|
|ear morphogenesis|
|embryonic limb morphogenesis|
|embryonic appendage morphogenesis|
|osteoblast differentiation|
|positive regulation of canonical Wnt signaling pathway|
|limb morphogenesis|
|appendage morphogenesis|
|positive regulation of Wnt signaling pathway|
|central nervous system neuron differentiation|
|appendage development|
|limb development|
|positive regulation of epithelial cell proliferation|
|inner ear development|
|respiratory system development|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|bone development|
|transcription regulatory region DNA binding|
|ear development|
|nuclear chromatin|
|skeletal system morphogenesis|
|sensory organ morphogenesis|
|telencephalon development|
|axon guidance|
|neuron projection guidance|
|ossification|
|regulation of canonical Wnt signaling pathway|
|embryonic organ morphogenesis|
|regulation of epithelial cell proliferation|
|regulation of Wnt signaling pathway|
|axonogenesis|
|forebrain development|
|axon development|
|sequence-specific DNA binding|
|cell morphogenesis involved in neuron differentiation|
|embryonic organ development|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|skeletal system development|
|cellular response to growth factor stimulus|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|cell part morphogenesis|
|response to growth factor|
|sensory organ development|
|chemotaxis|
|taxis|
|cell population proliferation|
|cell morphogenesis involved in differentiation|
|embryonic morphogenesis|
|neuron projection development|
|DNA-binding transcription factor activity|
|epithelial cell differentiation|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|brain development|
|head development|
|neuron development|
|cellular component morphogenesis|
|anatomical structure formation involved in morphogenesis|
|positive regulation of cell population proliferation|
|animal organ morphogenesis|
|embryo development|
|central nervous system development|
|neuron differentiation|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|locomotion|
|response to endogenous stimulus|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|positive regulation of signal transduction|
|positive regulation of RNA metabolic process|
|tissue development|
|positive regulation of cell communication|
|positive regulation of signaling|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12422
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DLX5 Expression in NALM6 Cells: -3.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>