DNAJC11 [The Human Chemical-Genetic Interaction Map Project]

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======= DNAJC11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DNAJC11
  * **<color #00a2e8>Official Name</color>**: DnaJ heat shock protein family (Hsp40) member C11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55735|55735]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NVH1|Q9NVH1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DNAJC11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DNAJC11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614827|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Isoform 1: Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex. {ECO:0000269|PubMed:25111180, ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF3395|
|DnaJ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|SAM complex|
|MICOS complex|
|cristae formation|
|inner mitochondrial membrane organization|
|mitochondrial membrane organization|
|mitochondrion organization|
|membrane organization|
|mitochondrion|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|1.78|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.82|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|1.86|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|2.06|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.12|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|2.23|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.486|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 170/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|10/28|
|blood|6/28|
|bone|4/26|
|breast|7/33|
|central nervous system|12/56|
|cervix|0/4|
|colorectal|7/17|
|esophagus|6/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|6/21|
|liver|5/20|
|lung|18/75|
|lymphocyte|5/16|
|ovary|3/26|
|pancreas|4/24|
|peripheral nervous system|1/16|
|plasma cell|5/15|
|prostate|0/1|
|skin|8/24|
|soft tissue|4/9|
|thyroid|0/2|
|upper aerodigestive|10/22|
|urinary tract|6/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 78
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.57 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DNAJC11 Expression in NALM6 Cells: 6.57'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>