DNAJC13 [The Human Chemical-Genetic Interaction Map Project]

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======= DNAJC13 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DNAJC13
  * **<color #00a2e8>Official Name</color>**: DnaJ heat shock protein family (Hsp40) member C13
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23317|23317]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75165|O75165]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DNAJC13&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DNAJC13|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614334|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the Dnaj protein family whose members act as co-chaperones of a partner heat-shock protein by binding to the latter and stimulating ATP hydrolysis. The encoded protein associates with the heat-shock protein Hsc70 and plays a role in clathrin-mediated endocytosis. It may also be involved in post-endocytic transport mechanisms via its associations with other proteins, including the sorting nexin SNX1. Mutations in this gene are associated with Parkinson's disease. [provided by RefSeq, Jun 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DnaJ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of early endosome to recycling endosome transport|
|WASH complex|
|regulation of early endosome to late endosome transport|
|regulation of cytoplasmic transport|
|azurophil granule membrane|
|endosome organization|
|secretory granule membrane|
|osteoblast differentiation|
|early endosome membrane|
|endosome membrane|
|receptor-mediated endocytosis|
|ossification|
|lysosomal membrane|
|vesicle organization|
|regulation of intracellular transport|
|endomembrane system organization|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|regulation of vesicle-mediated transport|
|endocytosis|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|import into cell|
|intracellular membrane-bounded organelle|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|regulation of cellular localization|
|leukocyte activation|
|secretion by cell|
|export from cell|
|cell activation|
|immune effector process|
|secretion|
|protein transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|nitrogen compound transport|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|-3.3|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-2.42|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|-2.17|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-2.12|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-2.1|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|-2.08|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|-1.88|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|-1.81|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|-1.79|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.86|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|1.9|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|1.97|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|3.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 23/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|3/20|
|lung|3/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13591
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DNAJC13 Expression in NALM6 Cells: 6.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>