DNAJC30 [The Human Chemical-Genetic Interaction Map Project]

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======= DNAJC30 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DNAJC30
  * **<color #00a2e8>Official Name</color>**: DnaJ heat shock protein family (Hsp40) member C30
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84277|84277]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96LL9|Q96LL9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DNAJC30&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DNAJC30|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618202|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DnaJ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of mitochondrial ATP synthesis coupled proton transport|
|regulation of ATP biosynthetic process|
|regulation of proton transport|
|regulation of oxidative phosphorylation|
|ATP biosynthetic process|
|regulation of purine nucleotide biosynthetic process|
|regulation of nucleotide biosynthetic process|
|purine ribonucleoside triphosphate biosynthetic process|
|purine nucleoside triphosphate biosynthetic process|
|ribonucleoside triphosphate biosynthetic process|
|purine ribonucleoside triphosphate metabolic process|
|nucleoside triphosphate biosynthetic process|
|ribonucleoside triphosphate metabolic process|
|purine nucleoside triphosphate metabolic process|
|nucleoside triphosphate metabolic process|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|regulation of ATP metabolic process|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|regulation of generation of precursor metabolites and energy|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|ATP metabolic process|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|regulation of cation transmembrane transport|
|ribose phosphate metabolic process|
|regulation of intracellular transport|
|purine-containing compound metabolic process|
|mitochondrial inner membrane|
|regulation of small molecule metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|regulation of ion transmembrane transport|
|drug metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|regulation of transmembrane transport|
|carbohydrate derivative biosynthetic process|
|regulation of ion transport|
|brain development|
|head development|
|organophosphate metabolic process|
|regulation of cellular localization|
|central nervous system development|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|regulation of phosphorylation|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-1.97|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.79|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.81|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|1.89|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|1.95|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|2.31|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|3.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7429
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DNAJC30 Expression in NALM6 Cells: 3.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>