DNAJC5 [The Human Chemical-Genetic Interaction Map Project]

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======= DNAJC5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DNAJC5
  * **<color #00a2e8>Official Name</color>**: DnaJ heat shock protein family (Hsp40) member C5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80331|80331]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H3Z4|Q9H3Z4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DNAJC5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DNAJC5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611203|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. The encoded protein plays a role in membrane trafficking and protein folding, and has been shown to have anti-neurodegenerative properties. The encoded protein is known to play a role in cystic fibrosis and Huntington's disease. A pseudogene of this gene is located on the short arm of chromosome 8. [provided by RefSeq, Nov 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a general chaperone in regulated exocytosis (By similarity). Acts as a co-chaperone for the SNARE protein SNAP-25 (By similarity). Involved in the calcium-mediated control of a late stage of exocytosis (By similarity). May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity). {ECO:0000250|UniProtKB:P60904, ECO:0000250|UniProtKB:Q29455}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DnaJ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ATP-dependent protein binding|
|clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane|
|anchored component of synaptic vesicle membrane|
|chaperone-mediated protein folding|
|azurophil granule membrane|
|synaptic vesicle exocytosis|
|neuromuscular junction|
|specific granule membrane|
|melanosome|
|neurotransmitter secretion|
|signal release from synapse|
|regulation of synaptic vesicle cycle|
|synaptic vesicle cycle|
|vesicle-mediated transport in synapse|
|negative regulation of neuron apoptotic process|
|signal release|
|neurotransmitter transport|
|regulation of neuron apoptotic process|
|negative regulation of neuron death|
|protein folding|
|lysosomal membrane|
|regulation of neuron death|
|regulation of neurotransmitter levels|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|trans-synaptic signaling|
|synaptic signaling|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|regulation of vesicle-mediated transport|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cellular localization|
|leukocyte activation|
|negative regulation of cell death|
|secretion by cell|
|export from cell|
|cell activation|
|immune effector process|
|cell-cell signaling|
|secretion|
|mitochondrion|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell death|
|establishment of localization in cell|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|-2.16|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-2.02|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|-1.85|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-1.77|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.7|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.82|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18950
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DNAJC5 Expression in NALM6 Cells: 6.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>