DNAJC8 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= DNAJC8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DNAJC8
  * **<color #00a2e8>Official Name</color>**: DnaJ heat shock protein family (Hsp40) member C8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22826|22826]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75937|O75937]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DNAJC8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DNAJC8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Suppresses polyglutamine (polyQ) aggregation of ATXN3 in neuronal cells (PubMed:27133716). {ECO:0000269|PubMed:27133716}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DnaJ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Hsp70 protein binding|
|intercellular bridge|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|mRNA processing|
|mRNA metabolic process|
|RNA processing|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-2.4|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-2.4|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-2.19|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|-1.96|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.89|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-1.87|
|[[:results:exp169|BH1 1μM R04 exp169]]|-1.82|
|[[:results:exp275|Citral 75μM R06 exp275]]|-1.77|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-1.75|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.71|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|1.97|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|2.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:atrx|ATRX]]|0.408|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 136/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|7/28|
|blood|3/28|
|bone|3/26|
|breast|8/33|
|central nervous system|9/56|
|cervix|1/4|
|colorectal|3/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|7/21|
|liver|4/20|
|lung|17/75|
|lymphocyte|7/16|
|ovary|4/26|
|pancreas|6/24|
|peripheral nervous system|2/16|
|plasma cell|1/15|
|prostate|1/1|
|skin|6/24|
|soft tissue|4/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|4/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4285
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DNAJC8 Expression in NALM6 Cells: 6.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>