DNLZ [The Human Chemical-Genetic Interaction Map Project]

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======= DNLZ =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DNLZ
  * **<color #00a2e8>Official Name</color>**: DNL-type zinc finger
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=728489|728489]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5SXM8|Q5SXM8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DNLZ&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DNLZ|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620797|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May function as a co-chaperone towards HSPA9/mortalin which, by itself, is prone to self-aggregation. {ECO:0000269|PubMed:23462535}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-DNL|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein import into mitochondrial matrix|
|protein transmembrane import into intracellular organelle|
|intracellular protein transmembrane transport|
|protein targeting to mitochondrion|
|protein transmembrane transport|
|establishment of protein localization to mitochondrion|
|protein localization to mitochondrion|
|mitochondrial transmembrane transport|
|chaperone binding|
|protein import|
|protein stabilization|
|mitochondrial transport|
|protein folding|
|regulation of protein stability|
|protein targeting|
|establishment of protein localization to organelle|
|mitochondrion organization|
|protein localization to organelle|
|zinc ion binding|
|intracellular protein transport|
|mitochondrion|
|transmembrane transport|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|-1.79|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.7|
|[[:results:exp135|MS023 7μM R03 exp135]]|1.72|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|1.74|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.75|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.78|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|1.82|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|1.83|
|[[:results:exp504|MK2206 4μM R08 exp504]]|1.84|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|1.86|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|1.93|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.99|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|2|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.01|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2.03|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.08|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.1|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.11|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.13|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|2.13|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|2.41|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.47|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:trmt61a|TRMT61A]]|0.645|
|[[:human genes:p:ptpmt1|PTPMT1]]|0.64|
|[[:human genes:r:romo1|ROMO1]]|0.63|
|[[:human genes:p:pgm3|PGM3]]|0.629|
|[[:human genes:p:pmvk|PMVK]]|0.616|
|[[:human genes:p:ppcdc|PPCDC]]|0.614|
|[[:human genes:c:crls1|CRLS1]]|0.583|
|[[:human genes:t:thg1l|THG1L]]|0.582|
|[[:human genes:r:rpia|RPIA]]|0.581|
|[[:human genes:p:pgs1|PGS1]]|0.581|
|[[:human genes:t:triap1|TRIAP1]]|0.581|
|[[:human genes:p:pars2|PARS2]]|0.58|
|[[:human genes:s:slc25a26|SLC25A26]]|0.562|
|[[:human genes:p:ppcs|PPCS]]|0.561|
|[[:human genes:t:taz|TAZ]]|0.554|
|[[:human genes:m:mrps34|MRPS34]]|0.551|
|[[:human genes:t:tamm41|TAMM41]]|0.548|
|[[:human genes:o:opa1|OPA1]]|0.548|
|[[:human genes:d:dhrsx|DHRSX]]|0.547|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.542|
|[[:human genes:t:tmem242|TMEM242]]|0.542|
|[[:human genes:t:trmt6|TRMT6]]|0.542|
|[[:human genes:m:mrpl23|MRPL23]]|0.541|
|[[:human genes:d:dap3|DAP3]]|0.537|
|[[:human genes:t:ten1|TEN1]]|0.537|
|[[:human genes:f:fh|FH]]|0.532|
|[[:human genes:r:rbfa|RBFA]]|0.531|
|[[:human genes:m:mrpl21|MRPL21]]|0.53|
|[[:human genes:y:yars2|YARS2]]|0.528|
|[[:human genes:g:gatc|GATC]]|0.527|
|[[:human genes:r:rft1|RFT1]]|0.524|
|[[:human genes:n:nars2|NARS2]]|0.523|
|[[:human genes:l:lsm10|LSM10]]|0.523|
|[[:human genes:m:mrps5|MRPS5]]|0.516|
|[[:human genes:d:dohh|DOHH]]|0.516|
|[[:human genes:t:tars2|TARS2]]|0.514|
|[[:human genes:d:dars2|DARS2]]|0.514|
|[[:human genes:g:gemin6|GEMIN6]]|0.512|
|[[:human genes:s:sco2|SCO2]]|0.511|
|[[:human genes:m:mrps18a|MRPS18A]]|0.509|
|[[:human genes:r:rars2|RARS2]]|0.506|
|[[:human genes:m:mettl1|METTL1]]|0.506|
|[[:human genes:m:mrps6|MRPS6]]|0.505|
|[[:human genes:m:mrps14|MRPS14]]|0.504|
|[[:human genes:t:tkt|TKT]]|0.501|
|[[:human genes:s:srp14|SRP14]]|0.5|
|[[:human genes:h:hars2|HARS2]]|0.5|
|[[:human genes:k:kdsr|KDSR]]|0.499|
|[[:human genes:s:selrc1|SELRC1]]|0.498|
|[[:human genes:p:pmm2|PMM2]]|0.495|
|[[:human genes:s:srd5a3|SRD5A3]]|0.49|
|[[:human genes:a:atp5a1|ATP5A1]]|0.49|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.489|
|[[:human genes:v:vezt|VEZT]]|0.488|
|[[:human genes:e:ears2|EARS2]]|0.488|
|[[:human genes:b:bcs1l|BCS1L]]|0.486|
|[[:human genes:a:alg1|ALG1]]|0.486|
|[[:human genes:c:coq3|COQ3]]|0.485|
|[[:human genes:t:trmt10a|TRMT10A]]|0.484|
|[[:human genes:r:rpusd4|RPUSD4]]|0.484|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.482|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.476|
|[[:human genes:v:vars2|VARS2]]|0.476|
|[[:human genes:c:c1d|C1D]]|0.472|
|[[:human genes:f:fastkd5|FASTKD5]]|0.472|
|[[:human genes:g:gfm2|GFM2]]|0.47|
|[[:human genes:a:atic|ATIC]]|0.467|
|[[:human genes:g:gemin7|GEMIN7]]|0.466|
|[[:human genes:m:mrps16|MRPS16]]|0.464|
|[[:human genes:m:mrpl53|MRPL53]]|0.462|
|[[:human genes:u:uap1|UAP1]]|0.462|
|[[:human genes:a:alg6|ALG6]]|0.459|
|[[:human genes:d:ddx1|DDX1]]|0.459|
|[[:human genes:t:timm13|TIMM13]]|0.459|
|[[:human genes:a:atxn10|ATXN10]]|0.455|
|[[:human genes:t:tpk1|TPK1]]|0.455|
|[[:human genes:m:mrps21|MRPS21]]|0.453|
|[[:human genes:q:qrsl1|QRSL1]]|0.453|
|[[:human genes:a:atp5c1|ATP5C1]]|0.452|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.452|
|[[:human genes:a:atp5d|ATP5D]]|0.452|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.45|
|[[:human genes:r:rpe|RPE]]|0.449|
|[[:human genes:a:aars2|AARS2]]|0.449|
|[[:human genes:d:ddx39a|DDX39A]]|0.448|
|[[:human genes:d:dpagt1|DPAGT1]]|0.447|
|[[:human genes:m:mrps9|MRPS9]]|0.446|
|[[:human genes:s:sec62|SEC62]]|0.446|
|[[:human genes:p:pgls|PGLS]]|0.445|
|[[:human genes:m:mrps26|MRPS26]]|0.444|
|[[:human genes:p:pitrm1|PITRM1]]|0.443|
|[[:human genes:c:c15orf41|C15orf41]]|0.443|
|[[:human genes:m:mtg1|MTG1]]|0.441|
|[[:human genes:n:n6amt1|N6AMT1]]|0.44|
|[[:human genes:w:wbscr16|WBSCR16]]|0.44|
|[[:human genes:g:g6pd|G6PD]]|0.439|
|[[:human genes:m:mrpl20|MRPL20]]|0.438|
|[[:human genes:g:gemin8|GEMIN8]]|0.438|
|[[:human genes:c:cep57|CEP57]]|0.438|
|[[:human genes:g:gfm1|GFM1]]|0.437|
|[[:human genes:l:lars2|LARS2]]|0.437|
|[[:human genes:d:dolk|DOLK]]|0.436|
|[[:human genes:e:elp3|ELP3]]|0.435|
|[[:human genes:p:pdss1|PDSS1]]|0.433|
|[[:human genes:p:ppa1|PPA1]]|0.433|
|[[:human genes:t:ttc4|TTC4]]|0.433|
|[[:human genes:a:alg13|ALG13]]|0.431|
|[[:human genes:p:ppa2|PPA2]]|0.431|
|[[:human genes:t:tsen54|TSEN54]]|0.429|
|[[:human genes:u:urm1|URM1]]|0.428|
|[[:human genes:a:aldh18a1|ALDH18A1]]|0.428|
|[[:human genes:i:iba57|IBA57]]|0.427|
|[[:human genes:c:c12orf65|C12orf65]]|0.427|
|[[:human genes:f:fkbpl|FKBPL]]|0.425|
|[[:human genes:m:mrps2|MRPS2]]|0.424|
|[[:human genes:s:slc7a1|SLC7A1]]|0.424|
|[[:human genes:e:elp6|ELP6]]|0.423|
|[[:human genes:p:polg|POLG]]|0.422|
|[[:human genes:m:mrp63|MRP63]]|0.422|
|[[:human genes:a:atp5b|ATP5B]]|0.418|
|[[:human genes:m:mrpl47|MRPL47]]|0.418|
|[[:human genes:m:mre11a|MRE11A]]|0.417|
|[[:human genes:e:elp2|ELP2]]|0.414|
|[[:human genes:h:hccs|HCCS]]|0.413|
|[[:human genes:u:uqcc2|UQCC2]]|0.413|
|[[:human genes:r:rabggtb|RABGGTB]]|0.409|
|[[:human genes:n:nsd1|NSD1]]|0.408|
|[[:human genes:p:pet112|PET112]]|0.408|
|[[:human genes:m:mbtps2|MBTPS2]]|0.407|
|[[:human genes:c:ctu1|CTU1]]|0.407|
|[[:human genes:r:rpp21|RPP21]]|0.406|
|[[:human genes:p:pggt1b|PGGT1B]]|0.405|
|[[:human genes:m:mocs3|MOCS3]]|0.405|
|[[:human genes:p:pdcd5|PDCD5]]|0.405|
|[[:human genes:p:pdap1|PDAP1]]|0.403|
|[[:human genes:t:tomm6|TOMM6]]|0.403|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.403|
|[[:human genes:p:ptar1|PTAR1]]|0.402|
|[[:human genes:t:trnt1|TRNT1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 9/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|2/28|
|bone|0/26|
|breast|0/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 509
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DNLZ Expression in NALM6 Cells: 2.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>