DNM1 [The Human Chemical-Genetic Interaction Map Project]

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======= DNM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DNM1
  * **<color #00a2e8>Official Name</color>**: dynamin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1759|1759]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q05193|Q05193]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DNM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DNM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602377|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Dynamin N|
|Dynamin M|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|postsynaptic endocytic zone membrane|
|D2 dopamine receptor binding|
|presynaptic endocytic zone membrane|
|synaptic vesicle budding from presynaptic endocytic zone membrane|
|postsynaptic neurotransmitter receptor internalization|
|postsynaptic endocytosis|
|photoreceptor ribbon synapse|
|positive regulation of synaptic vesicle endocytosis|
|varicosity|
|membrane coat|
|synaptic vesicle budding|
|positive regulation of synaptic vesicle recycling|
|dendritic spine head|
|G protein-coupled receptor internalization|
|neurotransmitter receptor internalization|
|nitric-oxide synthase binding|
|regulation of synaptic vesicle endocytosis|
|desensitization of G protein-coupled receptor signaling pathway|
|negative adaptation of signaling pathway|
|adaptation of signaling pathway|
|regulation of synaptic vesicle recycling|
|neurotransmitter receptor transport|
|synaptic vesicle transport|
|toxin transport|
|synaptic vesicle localization|
|presynaptic endocytosis|
|synaptic vesicle endocytosis|
|regulation of postsynaptic membrane neurotransmitter receptor levels|
|negative regulation of G protein-coupled receptor signaling pathway|
|response to amyloid-beta|
|photoreceptor inner segment|
|synaptic vesicle recycling|
|receptor internalization|
|endosome organization|
|ephrin receptor signaling pathway|
|vesicle budding from membrane|
|positive regulation of endocytosis|
|receptor metabolic process|
|regulation of synaptic vesicle cycle|
|synaptic vesicle cycle|
|synaptic vesicle|
|vesicle-mediated transport in synapse|
|SH3 domain binding|
|regulation of G protein-coupled receptor signaling pathway|
|dendritic spine|
|establishment of vesicle localization|
|vesicle localization|
|protein C-terminus binding|
|postsynaptic membrane|
|regulation of endocytosis|
|regulation of synapse structure or activity|
|receptor-mediated endocytosis|
|microtubule binding|
|cytoplasmic vesicle|
|postsynaptic density|
|protein-containing complex localization|
|protein-containing complex binding|
|synapse|
|axon|
|vesicle organization|
|microtubule|
|GTPase activity|
|glutamatergic synapse|
|establishment of organelle localization|
|GTP binding|
|endomembrane system organization|
|establishment of protein localization to organelle|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|protein kinase binding|
|response to peptide|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of vesicle-mediated transport|
|endocytosis|
|organelle localization|
|import into cell|
|enzyme linked receptor protein signaling pathway|
|protein localization to organelle|
|membrane organization|
|regulation of cellular localization|
|Golgi apparatus|
|positive regulation of transport|
|response to organonitrogen compound|
|identical protein binding|
|response to nitrogen compound|
|positive regulation of cellular component organization|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|RNA binding|
|protein transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|negative regulation of response to stimulus|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8973
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DNM1 Expression in NALM6 Cells: 6.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>