DNM1L [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= DNM1L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DNM1L
  * **<color #00a2e8>Official Name</color>**: dynamin 1 like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10059|10059]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00429|O00429]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DNM1L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DNM1L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603850|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the dynamin superfamily of GTPases. The encoded protein mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Dynamin N|
|GED|
|Dynamin M|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|BH2 domain binding|
|response to thapsigargin|
|mitochondrial membrane fission|
|cellular response to thapsigargin|
|mitochondrion-derived vesicle|
|regulation of peroxisome organization|
|response to flavonoid|
|synaptic vesicle recycling via endosome|
|response to hypobaric hypoxia|
|dynamin family protein polymerization involved in mitochondrial fission|
|dynamin family protein polymerization involved in membrane fission|
|presynaptic endocytic zone membrane|
|negative regulation of mitochondrial fusion|
|synaptic vesicle endosomal processing|
|positive regulation of synaptic vesicle endocytosis|
|response to oxygen-glucose deprivation|
|cellular response to oxygen-glucose deprivation|
|regulation of mitochondrial fusion|
|positive regulation of synaptic vesicle recycling|
|intracellular distribution of mitochondria|
|positive regulation of synaptic vesicle exocytosis|
|peroxisome fission|
|mitochondrial fragmentation involved in apoptotic process|
|membrane fission|
|positive regulation of mitochondrial fission|
|regulation of synaptic vesicle endocytosis|
|mitochondrion distribution|
|mitochondrial fission|
|positive regulation of dendritic spine morphogenesis|
|positive regulation of neurotransmitter secretion|
|mitochondrion morphogenesis|
|release of cytochrome c from mitochondria|
|GTP-dependent protein binding|
|regulation of ubiquitin protein ligase activity|
|regulation of mitochondrial fission|
|necroptotic process|
|regulation of synaptic vesicle recycling|
|programmed necrotic cell death|
|necrotic cell death|
|positive regulation of release of cytochrome c from mitochondria|
|positive regulation of dendrite morphogenesis|
|positive regulation of neurotransmitter transport|
|clathrin binding|
|regulation of autophagy of mitochondrion|
|regulation of protein oligomerization|
|positive regulation of dendritic spine development|
|regulation of dendritic spine morphogenesis|
|synaptic vesicle endocytosis|
|presynaptic endocytosis|
|mitochondrion localization|
|regulation of release of cytochrome c from mitochondria|
|regulation of ubiquitin-protein transferase activity|
|brush border|
|synaptic vesicle recycling|
|execution phase of apoptosis|
|positive regulation of regulated secretory pathway|
|negative regulation of mitochondrion organization|
|clathrin-coated pit|
|endoplasmic reticulum organization|
|positive regulation of intrinsic apoptotic signaling pathway|
|apoptotic mitochondrial changes|
|synaptic vesicle membrane|
|regulation of dendritic spine development|
|positive regulation of dendrite development|
|protein localization to mitochondrion|
|regulation of synaptic vesicle exocytosis|
|peroxisome organization|
|heart contraction|
|protein polymerization|
|positive regulation of exocytosis|
|regulation of dendrite morphogenesis|
|protein homotetramerization|
|regulation of postsynapse organization|
|heart process|
|positive regulation of endocytosis|
|mitochondrial membrane|
|regulation of neurotransmitter secretion|
|peroxisome|
|regulation of synaptic vesicle cycle|
|positive regulation of mitochondrion organization|
|synaptic vesicle cycle|
|regulation of ATP metabolic process|
|vesicle-mediated transport in synapse|
|membrane fusion|
|regulation of neurotransmitter transport|
|protein tetramerization|
|Rab GTPase binding|
|regulation of dendrite development|
|positive regulation of synaptic transmission|
|lipid binding|
|positive regulation of cell morphogenesis involved in differentiation|
|regulation of intrinsic apoptotic signaling pathway|
|mitochondrial outer membrane|
|regulation of regulated secretory pathway|
|positive regulation of apoptotic signaling pathway|
|regulation of mitochondrion organization|
|cellular response to decreased oxygen levels|
|regulation of protein ubiquitination|
|regulation of endocytosis|
|cellular response to oxygen levels|
|regulation of synapse organization|
|regulation of exocytosis|
|regulation of synapse structure or activity|
|regulation of protein modification by small protein conjugation or removal|
|endosomal transport|
|cellular response to nutrient levels|
|microtubule binding|
|calcium ion transport|
|cellular response to extracellular stimulus|
|protein-containing complex binding|
|positive regulation of protein secretion|
|rhythmic process|
|positive regulation of neuron projection development|
|GTPase activator activity|
|apoptotic signaling pathway|
|positive regulation of peptide secretion|
|ubiquitin protein ligase binding|
|divalent metal ion transport|
|divalent inorganic cation transport|
|regulation of cell morphogenesis involved in differentiation|
|organelle fission|
|microtubule|
|GTPase activity|
|regulation of autophagy|
|cellular response to external stimulus|
|protein homooligomerization|
|response to hypoxia|
|regulation of neurotransmitter levels|
|response to decreased oxygen levels|
|positive regulation of neuron differentiation|
|negative regulation of organelle organization|
|response to oxygen levels|
|positive regulation of cell projection organization|
|GTP binding|
|blood circulation|
|circulatory system process|
|regulation of apoptotic signaling pathway|
|positive regulation of secretion by cell|
|positive regulation of GTPase activity|
|endomembrane system organization|
|positive regulation of protein transport|
|positive regulation of secretion|
|modulation of chemical synaptic transmission|
|mitochondrion organization|
|regulation of trans-synaptic signaling|
|regulation of protein complex assembly|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|positive regulation of neurogenesis|
|regulation of GTPase activity|
|regulation of cell morphogenesis|
|regulation of peptide secretion|
|regulation of neuron projection development|
|response to nutrient levels|
|cell part morphogenesis|
|protein complex oligomerization|
|cellular response to lipid|
|response to extracellular stimulus|
|positive regulation of nervous system development|
|positive regulation of cell development|
|cellular response to organic cyclic compound|
|cell junction|
|regulation of vesicle-mediated transport|
|endocytosis|
|organelle localization|
|protein-containing complex|
|Golgi membrane|
|positive regulation of organelle organization|
|metal ion transport|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|regulation of neuron differentiation|
|import into cell|
|intracellular membrane-bounded organelle|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|perinuclear region of cytoplasm|
|negative regulation of cellular component organization|
|regulation of protein transport|
|regulation of cell projection organization|
|protein localization to organelle|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|positive regulation of hydrolase activity|
|regulation of secretion|
|regulation of neurogenesis|
|cellular component morphogenesis|
|cation transport|
|regulation of cellular catabolic process|
|cellular protein-containing complex assembly|
|response to lipid|
|membrane organization|
|protein homodimerization activity|
|regulation of cellular localization|
|response to organic cyclic compound|
|apoptotic process|
|regulation of nervous system development|
|regulation of cell development|
|endoplasmic reticulum membrane|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|Golgi apparatus|
|positive regulation of transport|
|regulation of catabolic process|
|endoplasmic reticulum|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|programmed cell death|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|cell death|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|mitochondrion|
|regulation of hydrolase activity|
|regulation of organelle organization|
|positive regulation of developmental process|
|ion transport|
|positive regulation of catalytic activity|
|intracellular transport|
|generation of neurons|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|cellular protein localization|
|cellular macromolecule localization|
|neurogenesis|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|vesicle-mediated transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.96|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.82|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|-1.79|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-1.76|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.77|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|1.98|
|[[:results:exp534|Trientine 500μM R08 exp534]]|2.22|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 174/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|3/28|
|blood|5/28|
|bone|5/26|
|breast|13/33|
|central nervous system|8/56|
|cervix|1/4|
|colorectal|3/17|
|esophagus|5/13|
|fibroblast|0/1|
|gastric|3/16|
|kidney|8/21|
|liver|4/20|
|lung|27/75|
|lymphocyte|1/16|
|ovary|9/26|
|pancreas|11/24|
|peripheral nervous system|1/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|5/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|3/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 374
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DNM1L Expression in NALM6 Cells: 6.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>