DNM3 [The Human Chemical-Genetic Interaction Map Project]

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======= DNM3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DNM3
  * **<color #00a2e8>Official Name</color>**: dynamin 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26052|26052]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UQ16|Q9UQ16]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DNM3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DNM3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611445|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Dynamin N|
|PH|
|GED|
|Dynamin M|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|type 1 metabotropic glutamate receptor binding|
|basal tubulobulbar complex|
|apical tubulobulbar complex|
|structural constituent of postsynapse|
|postsynaptic endocytic zone membrane|
|synaptic vesicle budding from presynaptic endocytic zone membrane|
|type 5 metabotropic glutamate receptor binding|
|postsynaptic endocytosis|
|postsynaptic neurotransmitter receptor internalization|
|negative regulation of dendritic spine morphogenesis|
|synaptic vesicle budding|
|dendritic spine head|
|positive regulation of synaptic vesicle recycling|
|neurotransmitter receptor internalization|
|negative regulation of dendritic spine development|
|synaptic cleft|
|nitric-oxide synthase binding|
|negative regulation of dendrite morphogenesis|
|filopodium assembly|
|negative regulation of synapse organization|
|regulation of synaptic vesicle recycling|
|negative regulation of dendrite development|
|positive regulation of filopodium assembly|
|neurotransmitter receptor transport|
|synaptic vesicle transport|
|synaptic vesicle localization|
|regulation of dendritic spine morphogenesis|
|synaptic vesicle endocytosis|
|presynaptic endocytosis|
|regulation of filopodium assembly|
|regulation of postsynaptic membrane neurotransmitter receptor levels|
|photoreceptor inner segment|
|synaptic vesicle recycling|
|receptor internalization|
|regulation of dendritic spine development|
|postsynapse organization|
|regulation of dendrite morphogenesis|
|synapse assembly|
|presynapse|
|vesicle budding from membrane|
|regulation of postsynapse organization|
|negative regulation of cell morphogenesis involved in differentiation|
|positive regulation of plasma membrane bounded cell projection assembly|
|receptor metabolic process|
|regulation of synaptic vesicle cycle|
|synaptic vesicle cycle|
|vesicle-mediated transport in synapse|
|dendritic spine|
|regulation of dendrite development|
|negative regulation of neuron projection development|
|establishment of vesicle localization|
|negative regulation of cell projection organization|
|vesicle localization|
|regulation of plasma membrane bounded cell projection assembly|
|postsynaptic membrane|
|regulation of cell projection assembly|
|regulation of synapse organization|
|negative regulation of neuron differentiation|
|regulation of synapse structure or activity|
|receptor-mediated endocytosis|
|microtubule binding|
|postsynaptic density|
|cytoplasmic vesicle|
|protein-containing complex localization|
|synapse|
|synapse organization|
|negative regulation of neurogenesis|
|axon|
|vesicle organization|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of nervous system development|
|microtubule|
|GTPase activity|
|negative regulation of cell development|
|glutamatergic synapse|
|establishment of organelle localization|
|positive regulation of cell projection organization|
|GTP binding|
|establishment of protein localization to organelle|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|positive regulation of cellular component biogenesis|
|regulation of vesicle-mediated transport|
|endocytosis|
|organelle localization|
|regulation of neuron differentiation|
|import into cell|
|regulation of plasma membrane bounded cell projection organization|
|perinuclear region of cytoplasm|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|protein localization to organelle|
|regulation of neurogenesis|
|membrane organization|
|regulation of cellular localization|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|Golgi apparatus|
|positive regulation of transport|
|regulation of anatomical structure morphogenesis|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|protein transport|
|generation of neurons|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|regulation of cell differentiation|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|1.74|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5628
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DNM3 Expression in NALM6 Cells: -0.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>