DNMT3A [The Human Chemical-Genetic Interaction Map Project]

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======= DNMT3A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DNMT3A
  * **<color #00a2e8>Official Name</color>**: DNA methyltransferase 3 alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1788|1788]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y6K1|Q9Y6K1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DNMT3A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DNMT3A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602769|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. [provided by RefSeq, Mar 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. {ECO:0000269|PubMed:16357870}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DNA methylase|
|PWWP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DNA (cytosine-5-)-methyltransferase activity|
|C-5 methylation of cytosine|
|DNA-methyltransferase activity|
|DNA methylation on cytosine|
|euchromatin|
|DNA methylation involved in embryo development|
|changes to DNA methylation involved in embryo development|
|hepatocyte apoptotic process|
|methylation-dependent chromatin silencing|
|XY body|
|cellular response to ethanol|
|regulation of gene expression by genetic imprinting|
|response to vitamin A|
|DNA methylation involved in gamete generation|
|nuclear heterochromatin|
|genetic imprinting|
|response to lead ion|
|epithelial cell apoptotic process|
|DNA alkylation|
|DNA methylation|
|chromosome, centromeric region|
|response to cocaine|
|chromatin silencing|
|chromatin organization involved in negative regulation of transcription|
|DNA methylation or demethylation|
|cellular response to amino acid stimulus|
|chromatin organization involved in regulation of transcription|
|response to anesthetic|
|negative regulation of gene expression, epigenetic|
|cellular response to alcohol|
|response to vitamin|
|DNA modification|
|nuclear matrix|
|response to alkaloid|
|response to amino acid|
|cellular response to antibiotic|
|response to ethanol|
|response to estradiol|
|response to ionizing radiation|
|gene silencing|
|response to ammonium ion|
|cellular response to hypoxia|
|cellular response to decreased oxygen levels|
|cellular response to acid chemical|
|cellular response to toxic substance|
|response to nutrient|
|cellular response to oxygen levels|
|response to alcohol|
|regulation of gene expression, epigenetic|
|transcription corepressor activity|
|macromolecule methylation|
|aging|
|response to xenobiotic stimulus|
|response to antibiotic|
|methylation|
|transcription factor binding|
|response to hypoxia|
|response to acid chemical|
|cellular process involved in reproduction in multicellular organism|
|response to decreased oxygen levels|
|response to metal ion|
|covalent chromatin modification|
|response to oxygen levels|
|chromatin binding|
|cellular response to drug|
|response to radiation|
|response to nutrient levels|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|response to toxic substance|
|response to extracellular stimulus|
|response to inorganic substance|
|spermatogenesis|
|male gamete generation|
|cellular response to organonitrogen compound|
|cellular response to nitrogen compound|
|mitotic cell cycle|
|gamete generation|
|positive regulation of cell death|
|chromatin organization|
|DNA metabolic process|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|response to hormone|
|response to organic cyclic compound|
|apoptotic process|
|embryo development|
|multi-organism reproductive process|
|response to organonitrogen compound|
|neuron differentiation|
|response to drug|
|programmed cell death|
|cellular response to oxygen-containing compound|
|chromosome organization|
|identical protein binding|
|response to nitrogen compound|
|cell death|
|response to abiotic stimulus|
|negative regulation of transcription, DNA-templated|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|neurogenesis|
|regulation of cell death|
|cellular response to stress|
|negative regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-2.05|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7806
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DNMT3A Expression in NALM6 Cells: 6.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>