DNTTIP1 [The Human Chemical-Genetic Interaction Map Project]

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======= DNTTIP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DNTTIP1
  * **<color #00a2e8>Official Name</color>**: deoxynucleotidyltransferase terminal interacting protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=116092|116092]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H147|Q9H147]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DNTTIP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DNTTIP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611388|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro) (PubMed:11473582). Also acts as a transcriptional regulator, binding to the consensus sequence 5'- GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA. {ECO:0000269|PubMed:11473582, ECO:0000269|PubMed:23874396, ECO:0000305|PubMed:25653165}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nucleosome binding|
|histone deacetylase complex|
|nucleolus|
|protein homodimerization activity|
|DNA binding|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2.71|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-2.32|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-2.1|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-2.1|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|-2.08|
|[[:results:exp11|CCCP 1μM R00 exp11]]|-1.99|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.93|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-1.92|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-1.89|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-1.86|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-1.84|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.83|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-1.8|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.77|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-1.76|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|2.29|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|2.62|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cnot8|CNOT8]]|0.418|
|[[:human genes:y:ypel5|YPEL5]]|0.414|
|[[:human genes:k:kdm6a|KDM6A]]|0.412|
|[[:human genes:e:elmsan1|ELMSAN1]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15529
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DNTTIP1 Expression in NALM6 Cells: 4.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>