DOC2B [The Human Chemical-Genetic Interaction Map Project]

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======= DOC2B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DOC2B
  * **<color #00a2e8>Official Name</color>**: double C2 domain beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8447|8447]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14184|Q14184]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DOC2B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DOC2B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604568|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  There are at least two protein isoforms of the Double C2 protein,  namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains.  DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2B is expressed ubiquitously and is suggested to be involved in Ca(2+)-dependent intracellular vesicle trafficking in various types of cells. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Calcium sensor which positively regulates SNARE- dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes (By similarity). {ECO:0000250, ECO:0000269|PubMed:9804756}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|spontaneous neurotransmitter secretion|
|spontaneous synaptic transmission|
|positive regulation of vesicle fusion|
|calcium ion-regulated exocytosis of neurotransmitter|
|positive regulation of calcium ion-dependent exocytosis|
|regulation of vesicle fusion|
|calcium-ion regulated exocytosis|
|regulation of calcium ion-dependent exocytosis|
|SNARE complex|
|positive regulation of regulated secretory pathway|
|syntaxin binding|
|calcium-dependent phospholipid binding|
|synaptic vesicle exocytosis|
|positive regulation of insulin secretion|
|positive regulation of exocytosis|
|presynapse|
|positive regulation of peptide hormone secretion|
|signal release from synapse|
|neurotransmitter secretion|
|synaptic vesicle cycle|
|positive regulation of hormone secretion|
|vesicle-mediated transport in synapse|
|regulation of regulated secretory pathway|
|signal release|
|regulation of insulin secretion|
|neurotransmitter transport|
|regulation of peptide hormone secretion|
|regulation of exocytosis|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|positive regulation of peptide secretion|
|regulation of neurotransmitter levels|
|positive regulation of secretion by cell|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|positive regulation of protein transport|
|positive regulation of secretion|
|trans-synaptic signaling|
|positive regulation of establishment of protein localization|
|synaptic signaling|
|regulation of protein secretion|
|regulation of peptide secretion|
|regulation of hormone levels|
|regulation of vesicle-mediated transport|
|positive regulation of organelle organization|
|regulated exocytosis|
|regulation of protein transport|
|calcium ion binding|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|exocytosis|
|regulation of secretion|
|positive regulation of transport|
|secretion by cell|
|regulation of protein localization|
|export from cell|
|cell-cell signaling|
|secretion|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8299
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.19 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DOC2B Expression in NALM6 Cells: 2.19'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>