DOCK10 [The Human Chemical-Genetic Interaction Map Project]

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======= DOCK10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DOCK10
  * **<color #00a2e8>Official Name</color>**: dedicator of cytokinesis 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55619|55619]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96BY6|Q96BY6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DOCK10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DOCK10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611518|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family are guanosine nucleotide exchange factors for Rho GTPases and defined by the presence of conserved DOCK-homology regions. The encoded protein belongs to the D (or Zizimin) subfamily of DOCK proteins, which also contain an N-terminal pleckstrin homology domain. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Mar 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression. {ECO:0000250|UniProtKB:Q8BZN6}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF3398|
|PH|
|Ded cyto|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|marginal zone B cell differentiation|
|mature B cell differentiation involved in immune response|
|dendritic spine morphogenesis|
|mature B cell differentiation|
|B cell homeostasis|
|dendritic spine development|
|dendritic spine organization|
|neuron projection organization|
|B cell activation involved in immune response|
|lymphocyte homeostasis|
|dendrite morphogenesis|
|leukocyte homeostasis|
|postsynapse organization|
|guanyl-nucleotide exchange factor activity|
|dendrite development|
|B cell differentiation|
|lymphocyte activation involved in immune response|
|dendritic spine|
|B cell activation|
|homeostasis of number of cells|
|lymphocyte differentiation|
|synapse organization|
|small GTPase mediated signal transduction|
|leukocyte differentiation|
|lymphocyte activation|
|positive regulation of GTPase activity|
|cell morphogenesis involved in neuron differentiation|
|neuron projection morphogenesis|
|regulation of GTPase activity|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell part morphogenesis|
|hemopoiesis|
|cell morphogenesis involved in differentiation|
|hematopoietic or lymphoid organ development|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|immune system development|
|neuron projection development|
|cell morphogenesis|
|molecular function|
|positive regulation of hydrolase activity|
|neuron development|
|cellular component morphogenesis|
|regulation of cell migration|
|regulation of cell motility|
|leukocyte activation|
|regulation of locomotion|
|regulation of cellular component movement|
|neuron differentiation|
|cell activation|
|immune effector process|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|generation of neurons|
|neurogenesis|
|homeostatic process|
|cell development|
|intracellular signal transduction|
|positive regulation of molecular function|
|immune response|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|-1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17458
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DOCK10 Expression in NALM6 Cells: 7.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>