DOCK2 [The Human Chemical-Genetic Interaction Map Project]

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======= DOCK2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DOCK2
  * **<color #00a2e8>Official Name</color>**: dedicator of cytokinesis 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1794|1794]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92608|Q92608]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DOCK2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DOCK2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603122|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. [provided by RefSeq, Oct 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. {ECO:0000269|PubMed:21613211}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ded cyto|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|membrane raft polarization|
|myeloid dendritic cell activation involved in immune response|
|alpha-beta T cell proliferation|
|membrane raft distribution|
|membrane raft localization|
|establishment of T cell polarity|
|establishment of lymphocyte polarity|
|T cell receptor binding|
|macropinocytosis|
|positive thymic T cell selection|
|negative thymic T cell selection|
|negative T cell selection|
|pinocytosis|
|immunological synapse formation|
|Rac guanyl-nucleotide exchange factor activity|
|thymic T cell selection|
|membrane raft organization|
|myeloid dendritic cell activation|
|positive T cell selection|
|regulation of defense response to virus by virus|
|T cell proliferation|
|T cell selection|
|T cell differentiation in thymus|
|alpha-beta T cell activation|
|specific granule lumen|
|positive regulation of phagocytosis|
|cell-cell recognition|
|lymphocyte proliferation|
|localization within membrane|
|mononuclear cell proliferation|
|regulation of phagocytosis|
|leukocyte proliferation|
|establishment of cell polarity|
|T cell differentiation|
|establishment or maintenance of cell polarity|
|T cell activation|
|lymphocyte differentiation|
|cell recognition|
|GTPase activator activity|
|small GTPase mediated signal transduction|
|leukocyte differentiation|
|cytoskeleton|
|lymphocyte activation|
|positive regulation of GTPase activity|
|regulation of GTPase activity|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|actin cytoskeleton organization|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|chemotaxis|
|regulation of vesicle-mediated transport|
|taxis|
|cell population proliferation|
|endocytosis|
|hemopoiesis|
|actin filament-based process|
|myeloid leukocyte activation|
|hematopoietic or lymphoid organ development|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|immune system development|
|import into cell|
|viral process|
|regulated exocytosis|
|leukocyte mediated immunity|
|positive regulation of hydrolase activity|
|symbiotic process|
|exocytosis|
|interspecies interaction between organisms|
|membrane organization|
|leukocyte activation|
|positive regulation of transport|
|secretion by cell|
|export from cell|
|cell activation|
|immune effector process|
|cytoskeleton organization|
|secretion|
|regulation of hydrolase activity|
|locomotion|
|positive regulation of catalytic activity|
|intracellular signal transduction|
|positive regulation of molecular function|
|regulation of transport|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|1.73|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|1.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10334
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DOCK2 Expression in NALM6 Cells: 7.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>