DOLPP1 [The Human Chemical-Genetic Interaction Map Project]

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======= DOLPP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DOLPP1
  * **<color #00a2e8>Official Name</color>**: dolichyldiphosphatase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57171|57171]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86YN1|Q86YN1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DOLPP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DOLPP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614516|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PAP2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dolichyldiphosphatase activity|
|dolichyl diphosphate metabolic process|
|dolichyl diphosphate biosynthetic process|
|dolichol-linked oligosaccharide biosynthetic process|
|oligosaccharide-lipid intermediate biosynthetic process|
|protein N-linked glycosylation|
|integral component of endoplasmic reticulum membrane|
|phospholipid biosynthetic process|
|macromolecule glycosylation|
|protein glycosylation|
|glycosylation|
|glycoprotein biosynthetic process|
|phospholipid metabolic process|
|glycoprotein metabolic process|
|organophosphate biosynthetic process|
|lipid biosynthetic process|
|carbohydrate derivative biosynthetic process|
|organophosphate metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|carbohydrate derivative metabolic process|
|lipid metabolic process|
|organonitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp16|DABN 2μM R00 exp16]]|1.87|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|2.1|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.25|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|2.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 16/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|1/24|
|peripheral nervous system|2/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3026
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DOLPP1 Expression in NALM6 Cells: 5.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>