DPAGT1 [The Human Chemical-Genetic Interaction Map Project]

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======= DPAGT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DPAGT1
  * **<color #00a2e8>Official Name</color>**: dolichyl-phosphate N-acetylglucosaminephosphotransferase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1798|1798]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H3H5|Q9H3H5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DPAGT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DPAGT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/191350|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is an enzyme that catalyzes the first step in the dolichol-linked oligosaccharide pathway for glycoprotein biosynthesis. This enzyme belongs to the glycosyltransferase family 4. This protein is an integral membrane protein of the endoplasmic reticulum. The congenital disorder of glycosylation type Ij is caused by mutation in the gene encoding this enzyme. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the initial step in the synthesis of dolichol- P-P-oligosaccharides.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glycos transf 4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phospho-N-acetylmuramoyl-pentapeptide-transferase activity|
|UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity|
|UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity|
|dolichol metabolic process|
|dolichyl diphosphate metabolic process|
|dolichyl diphosphate biosynthetic process|
|polyprenol metabolic process|
|UDP-N-acetylglucosamine metabolic process|
|transferase activity, transferring glycosyl groups|
|dolichol-linked oligosaccharide biosynthetic process|
|oligosaccharide-lipid intermediate biosynthetic process|
|nucleotide-sugar metabolic process|
|amino sugar metabolic process|
|protein N-linked glycosylation|
|integral component of endoplasmic reticulum membrane|
|isoprenoid metabolic process|
|phospholipid biosynthetic process|
|protein glycosylation|
|macromolecule glycosylation|
|glycosylation|
|alcohol metabolic process|
|glycoprotein biosynthetic process|
|phospholipid metabolic process|
|glycoprotein metabolic process|
|organic hydroxy compound metabolic process|
|protein complex oligomerization|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|lipid biosynthetic process|
|carbohydrate derivative biosynthetic process|
|intracellular membrane-bounded organelle|
|organophosphate metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|carbohydrate derivative metabolic process|
|lipid metabolic process|
|organonitrogen compound biosynthetic process|
|protein-containing complex assembly|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-4.4|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-4.23|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-3.67|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|-3.41|
|[[:results:exp218|A-395 10μM R05 exp218]]|-3.36|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-3.13|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|-2.78|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.75|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-2.7|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-2.67|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-2.67|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-2.61|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|-2.58|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|-2.56|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|-2.55|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|-2.54|
|[[:results:exp114|A-196 10μM R03 exp114]]|-2.53|
|[[:results:exp136|MS094 2μM R03 exp136]]|-2.52|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|-2.5|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|-2.45|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-2.44|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-2.44|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-2.4|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-2.38|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|-2.35|
|[[:results:exp534|Trientine 500μM R08 exp534]]|-2.34|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-2.33|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|-2.31|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-2.31|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|-2.27|
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|-2.26|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|-2.24|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|-2.22|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-2.22|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|-2.21|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|-2.18|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-2.13|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-2.13|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-2.12|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-2.1|
|[[:results:exp453|B02 10μM R08 exp453]]|-2.08|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-2.08|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-2.07|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|-2.06|
|[[:results:exp100|NFN1 1μM R03 exp100]]|-2.04|
|[[:results:exp16|DABN 2μM R00 exp16]]|-2.03|
|[[:results:exp219|A-395N 10μM R05 exp219]]|-2.02|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-2.01|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|-2|
|[[:results:exp124|GSK343 3μM R03 exp124]]|-1.98|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.97|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-1.97|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|-1.96|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|-1.91|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-1.91|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|-1.91|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|-1.9|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-1.9|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-1.9|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|-1.89|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-1.88|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-1.88|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|-1.87|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|-1.87|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-1.87|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-1.87|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|-1.86|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|-1.84|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|-1.84|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|-1.83|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-1.83|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|-1.83|
|[[:results:exp519|RS-1 10μM R08 exp519]]|-1.83|
|[[:results:exp302|35°C R06 exp302]]|-1.81|
|[[:results:exp115|A-366 10μM R03 exp115]]|-1.8|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|-1.8|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|-1.8|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|-1.8|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|-1.79|
|[[:results:exp132|Metformin 40μM R03 exp132]]|-1.79|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-1.79|
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|-1.78|
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|-1.78|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-1.77|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|-1.76|
|[[:results:exp433|LJH685 50μM R08 exp433]]|-1.74|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|-1.74|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-1.74|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|-1.71|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|-1.71|
|[[:results:exp392|PT-1 25μM R07 exp392]]|-1.71|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-1.7|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|1.9|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.92|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.94|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.98|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|2.03|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.04|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|2.08|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|2.21|
|[[:results:exp539|42°C R08 exp539]]|2.24|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.24|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.36|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.37|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.46|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|2.57|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|2.63|
|[[:results:exp532|TIC10 10μM R08 exp532]]|2.69|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|3.01|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|3.12|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|3.14|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|3.28|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pmm2|PMM2]]|0.763|
|[[:human genes:t:thg1l|THG1L]]|0.76|
|[[:human genes:a:alg1|ALG1]]|0.749|
|[[:human genes:g:gfpt1|GFPT1]]|0.736|
|[[:human genes:a:atxn10|ATXN10]]|0.721|
|[[:human genes:u:uap1|UAP1]]|0.708|
|[[:human genes:r:rtcb|RTCB]]|0.704|
|[[:human genes:t:triap1|TRIAP1]]|0.7|
|[[:human genes:g:gmppb|GMPPB]]|0.691|
|[[:human genes:r:rnmt|RNMT]]|0.666|
|[[:human genes:m:med16|MED16]]|0.664|
|[[:human genes:r:rptor|RPTOR]]|0.663|
|[[:human genes:d:dolk|DOLK]]|0.657|
|[[:human genes:d:dohh|DOHH]]|0.656|
|[[:human genes:a:alg2|ALG2]]|0.639|
|[[:human genes:s:srp14|SRP14]]|0.637|
|[[:human genes:a:alg13|ALG13]]|0.622|
|[[:human genes:a:adsl|ADSL]]|0.613|
|[[:human genes:c:ccdc101|CCDC101]]|0.613|
|[[:human genes:a:alg5|ALG5]]|0.61|
|[[:human genes:s:srd5a3|SRD5A3]]|0.607|
|[[:human genes:v:vezt|VEZT]]|0.607|
|[[:human genes:u:uhrf1|UHRF1]]|0.603|
|[[:human genes:o:oraov1|ORAOV1]]|0.603|
|[[:human genes:d:dad1|DAD1]]|0.602|
|[[:human genes:e:eny2|ENY2]]|0.602|
|[[:human genes:a:alg6|ALG6]]|0.6|
|[[:human genes:b:bap1|BAP1]]|0.596|
|[[:human genes:r:romo1|ROMO1]]|0.594|
|[[:human genes:r:rpe|RPE]]|0.594|
|[[:human genes:r:rpp21|RPP21]]|0.594|
|[[:human genes:g:gnb1l|GNB1L]]|0.59|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.59|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.589|
|[[:human genes:h:hspd1|HSPD1]]|0.588|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.588|
|[[:human genes:p:ppcs|PPCS]]|0.584|
|[[:human genes:t:tmem41b|TMEM41B]]|0.584|
|[[:human genes:t:tti2|TTI2]]|0.581|
|[[:human genes:p:pelo|PELO]]|0.58|
|[[:human genes:t:trmt5|TRMT5]]|0.577|
|[[:human genes:p:pam16|PAM16]]|0.576|
|[[:human genes:a:atp5j|ATP5J]]|0.576|
|[[:human genes:a:alg14|ALG14]]|0.575|
|[[:human genes:u:utp23|UTP23]]|0.574|
|[[:human genes:t:tsen54|TSEN54]]|0.574|
|[[:human genes:n:nae1|NAE1]]|0.574|
|[[:human genes:t:ttc4|TTC4]]|0.573|
|[[:human genes:m:mbtps2|MBTPS2]]|0.573|
|[[:human genes:t:tbca|TBCA]]|0.571|
|[[:human genes:c:cbfb|CBFB]]|0.57|
|[[:human genes:t:trnt1|TRNT1]]|0.57|
|[[:human genes:p:polr3h|POLR3H]]|0.563|
|[[:human genes:m:med4|MED4]]|0.561|
|[[:human genes:c:csnk2b|CSNK2B]]|0.561|
|[[:human genes:t:tti1|TTI1]]|0.56|
|[[:human genes:d:dhps|DHPS]]|0.558|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.554|
|[[:human genes:e:exoc4|EXOC4]]|0.554|
|[[:human genes:a:atp5b|ATP5B]]|0.552|
|[[:human genes:e:eif4e|EIF4E]]|0.552|
|[[:human genes:g:gtf2a2|GTF2A2]]|0.546|
|[[:human genes:d:dhrsx|DHRSX]]|0.544|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.542|
|[[:human genes:h:hccs|HCCS]]|0.541|
|[[:human genes:t:tamm41|TAMM41]]|0.541|
|[[:human genes:a:aars|AARS]]|0.539|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.538|
|[[:human genes:r:rpia|RPIA]]|0.537|
|[[:human genes:e:elac2|ELAC2]]|0.537|
|[[:human genes:d:ddx20|DDX20]]|0.536|
|[[:human genes:z:zrsr2|ZRSR2]]|0.536|
|[[:human genes:u:uso1|USO1]]|0.535|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.534|
|[[:human genes:u:ube2g2|UBE2G2]]|0.534|
|[[:human genes:s:slc25a26|SLC25A26]]|0.533|
|[[:human genes:a:atp5o|ATP5O]]|0.532|
|[[:human genes:f:fh|FH]]|0.529|
|[[:human genes:w:wdr59|WDR59]]|0.529|
|[[:human genes:t:trmt10a|TRMT10A]]|0.527|
|[[:human genes:a:atp2a2|ATP2A2]]|0.525|
|[[:human genes:c:cdipt|CDIPT]]|0.525|
|[[:human genes:f:fnta|FNTA]]|0.524|
|[[:human genes:v:vmp1|VMP1]]|0.524|
|[[:human genes:a:atic|ATIC]]|0.524|
|[[:human genes:p:ppa2|PPA2]]|0.523|
|[[:human genes:w:wdr24|WDR24]]|0.523|
|[[:human genes:e:eprs|EPRS]]|0.522|
|[[:human genes:t:telo2|TELO2]]|0.521|
|[[:human genes:t:timm22|TIMM22]]|0.52|
|[[:human genes:c:crls1|CRLS1]]|0.52|
|[[:human genes:t:taz|TAZ]]|0.52|
|[[:human genes:s:slc35b1|SLC35B1]]|0.519|
|[[:human genes:g:gemin8|GEMIN8]]|0.517|
|[[:human genes:t:thoc6|THOC6]]|0.516|
|[[:human genes:s:srp72|SRP72]]|0.515|
|[[:human genes:r:rad1|RAD1]]|0.515|
|[[:human genes:m:mllt1|MLLT1]]|0.515|
|[[:human genes:r:rft1|RFT1]]|0.515|
|[[:human genes:o:osgep|OSGEP]]|0.513|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.512|
|[[:human genes:u:uba3|UBA3]]|0.512|
|[[:human genes:t:tprkb|TPRKB]]|0.511|
|[[:human genes:y:yars|YARS]]|0.511|
|[[:human genes:g:gemin5|GEMIN5]]|0.509|
|[[:human genes:b:bub3|BUB3]]|0.508|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.507|
|[[:human genes:r:rabggtb|RABGGTB]]|0.507|
|[[:human genes:s:sec62|SEC62]]|0.505|
|[[:human genes:c:cep57|CEP57]]|0.505|
|[[:human genes:l:lsm11|LSM11]]|0.504|
|[[:human genes:d:ddx1|DDX1]]|0.504|
|[[:human genes:p:ppp4c|PPP4C]]|0.503|
|[[:human genes:l:lsm10|LSM10]]|0.502|
|[[:human genes:c:chchd4|CHCHD4]]|0.501|
|[[:human genes:r:rpn1|RPN1]]|0.5|
|[[:human genes:u:uxt|UXT]]|0.499|
|[[:human genes:g:gemin6|GEMIN6]]|0.499|
|[[:human genes:m:meaf6|MEAF6]]|0.499|
|[[:human genes:t:tsen34|TSEN34]]|0.498|
|[[:human genes:m:mtor|MTOR]]|0.497|
|[[:human genes:n:nars|NARS]]|0.497|
|[[:human genes:s:ssb|SSB]]|0.495|
|[[:human genes:p:polr3c|POLR3C]]|0.495|
|[[:human genes:c:casp9|CASP9]]|0.494|
|[[:human genes:e:eno1|ENO1]]|0.494|
|[[:human genes:v:vrk1|VRK1]]|0.494|
|[[:human genes:e:eef1e1|EEF1E1]]|0.494|
|[[:human genes:d:dnajc3|DNAJC3]]|0.494|
|[[:human genes:p:pdap1|PDAP1]]|0.493|
|[[:human genes:d:dr1|DR1]]|0.493|
|[[:human genes:r:rbm14|RBM14]]|0.493|
|[[:human genes:p:pyroxd1|PYROXD1]]|0.492|
|[[:human genes:n:nsmce1|NSMCE1]]|0.492|
|[[:human genes:h:haus8|HAUS8]]|0.491|
|[[:human genes:l:lsmd1|LSMD1]]|0.487|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.487|
|[[:human genes:p:polr3b|POLR3B]]|0.486|
|[[:human genes:s:srp68|SRP68]]|0.484|
|[[:human genes:s:slc25a19|SLC25A19]]|0.484|
|[[:human genes:m:mrps33|MRPS33]]|0.482|
|[[:human genes:t:tgs1|TGS1]]|0.482|
|[[:human genes:c:cct7|CCT7]]|0.481|
|[[:human genes:u:urm1|URM1]]|0.481|
|[[:human genes:t:timm13|TIMM13]]|0.48|
|[[:human genes:w:wdr92|WDR92]]|0.479|
|[[:human genes:t:tbp|TBP]]|0.479|
|[[:human genes:t:tbcb|TBCB]]|0.478|
|[[:human genes:m:med23|MED23]]|0.477|
|[[:human genes:b:bcs1l|BCS1L]]|0.477|
|[[:human genes:k:kdsr|KDSR]]|0.477|
|[[:human genes:e:elp3|ELP3]]|0.477|
|[[:human genes:t:ten1|TEN1]]|0.476|
|[[:human genes:d:ddost|DDOST]]|0.476|
|[[:human genes:w:wdr82|WDR82]]|0.475|
|[[:human genes:s:sdha|SDHA]]|0.475|
|[[:human genes:p:ppp6c|PPP6C]]|0.473|
|[[:human genes:d:dars2|DARS2]]|0.472|
|[[:human genes:s:sec63|SEC63]]|0.471|
|[[:human genes:d:dhdds|DHDDS]]|0.471|
|[[:human genes:t:tmed10|TMED10]]|0.47|
|[[:human genes:a:apaf1|APAF1]]|0.47|
|[[:human genes:p:plaa|PLAA]]|0.469|
|[[:human genes:m:mad2l1|MAD2L1]]|0.469|
|[[:human genes:m:mapk14|MAPK14]]|0.468|
|[[:human genes:c:cbx3|CBX3]]|0.468|
|[[:human genes:d:dpf2|DPF2]]|0.467|
|[[:human genes:m:med25|MED25]]|0.465|
|[[:human genes:t:tpk1|TPK1]]|0.464|
|[[:human genes:s:spcs2|SPCS2]]|0.464|
|[[:human genes:u:ube2j1|UBE2J1]]|0.462|
|[[:human genes:m:mrps14|MRPS14]]|0.461|
|[[:human genes:p:pgm3|PGM3]]|0.459|
|[[:human genes:t:tkt|TKT]]|0.459|
|[[:human genes:s:srprb|SRPRB]]|0.459|
|[[:human genes:p:pggt1b|PGGT1B]]|0.458|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.457|
|[[:human genes:o:otud5|OTUD5]]|0.456|
|[[:human genes:f:fgfr1op|FGFR1OP]]|0.456|
|[[:human genes:c:crcp|CRCP]]|0.455|
|[[:human genes:n:nsd1|NSD1]]|0.455|
|[[:human genes:m:mbtps1|MBTPS1]]|0.455|
|[[:human genes:a:alg9|ALG9]]|0.455|
|[[:human genes:z:zbtb11|ZBTB11]]|0.454|
|[[:human genes:g:gfer|GFER]]|0.454|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.454|
|[[:human genes:a:atp5a1|ATP5A1]]|0.453|
|[[:human genes:a:atp5h|ATP5H]]|0.453|
|[[:human genes:t:thoc3|THOC3]]|0.452|
|[[:human genes:c:cox16|COX16]]|0.452|
|[[:human genes:a:atp5d|ATP5D]]|0.452|
|[[:human genes:y:yars2|YARS2]]|0.452|
|[[:human genes:p:pdss1|PDSS1]]|0.452|
|[[:human genes:f:fntb|FNTB]]|0.451|
|[[:human genes:r:rfk|RFK]]|0.449|
|[[:human genes:v:vma21|VMA21]]|0.448|
|[[:human genes:u:ube2k|UBE2K]]|0.448|
|[[:human genes:d:dnlz|DNLZ]]|0.447|
|[[:human genes:t:txnl4b|TXNL4B]]|0.446|
|[[:human genes:t:txnrd1|TXNRD1]]|0.446|
|[[:human genes:d:dhx29|DHX29]]|0.445|
|[[:human genes:e:elp2|ELP2]]|0.442|
|[[:human genes:o:oip5|OIP5]]|0.441|
|[[:human genes:m:mrps6|MRPS6]]|0.439|
|[[:human genes:p:phb|PHB]]|0.439|
|[[:human genes:g:ggnbp2|GGNBP2]]|0.439|
|[[:human genes:a:actr10|ACTR10]]|0.438|
|[[:human genes:m:mrps11|MRPS11]]|0.438|
|[[:human genes:m:mars|MARS]]|0.437|
|[[:human genes:v:vhl|VHL]]|0.436|
|[[:human genes:d:ddx55|DDX55]]|0.436|
|[[:human genes:s:sec16a|SEC16A]]|0.436|
|[[:human genes:e:ercc2|ERCC2]]|0.434|
|[[:human genes:p:pik3r4|PIK3R4]]|0.434|
|[[:human genes:g:gemin7|GEMIN7]]|0.434|
|[[:human genes:z:znf259|ZNF259]]|0.434|
|[[:human genes:a:alg8|ALG8]]|0.434|
|[[:human genes:e:exoc3|EXOC3]]|0.434|
|[[:human genes:g:gpn2|GPN2]]|0.433|
|[[:human genes:q:qars|QARS]]|0.433|
|[[:human genes:t:trmt61a|TRMT61A]]|0.433|
|[[:human genes:c:c10orf2|C10orf2]]|0.433|
|[[:human genes:f:faf2|FAF2]]|0.433|
|[[:human genes:s:snapc5|SNAPC5]]|0.432|
|[[:human genes:e:eif1ax|EIF1AX]]|0.432|
|[[:human genes:u:ube3a|UBE3A]]|0.432|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.432|
|[[:human genes:s:sec61g|SEC61G]]|0.431|
|[[:human genes:g:gtf3a|GTF3A]]|0.43|
|[[:human genes:t:tufm|TUFM]]|0.43|
|[[:human genes:c:cmtr1|CMTR1]]|0.429|
|[[:human genes:f:fli1|FLI1]]|0.428|
|[[:human genes:d:ddx39a|DDX39A]]|0.427|
|[[:human genes:x:xpo6|XPO6]]|0.427|
|[[:human genes:o:opa1|OPA1]]|0.426|
|[[:human genes:n:nat9|NAT9]]|0.425|
|[[:human genes:n:nupl2|NUPL2]]|0.425|
|[[:human genes:m:mrps16|MRPS16]]|0.425|
|[[:human genes:s:sars2|SARS2]]|0.425|
|[[:human genes:m:mis18a|MIS18A]]|0.424|
|[[:human genes:b:bak1|BAK1]]|0.424|
|[[:human genes:c:c17orf89|C17orf89]]|0.422|
|[[:human genes:s:srrd|SRRD]]|0.422|
|[[:human genes:m:mrps18a|MRPS18A]]|0.421|
|[[:human genes:g:gfm1|GFM1]]|0.421|
|[[:human genes:d:derl2|DERL2]]|0.421|
|[[:human genes:s:stt3a|STT3A]]|0.421|
|[[:human genes:m:mrpl23|MRPL23]]|0.42|
|[[:human genes:s:sox7|SOX7]]|0.419|
|[[:human genes:s:snf8|SNF8]]|0.419|
|[[:human genes:l:lmo2|LMO2]]|0.418|
|[[:human genes:e:eif3f|EIF3F]]|0.418|
|[[:human genes:t:taf1a|TAF1A]]|0.417|
|[[:human genes:d:dpm3|DPM3]]|0.417|
|[[:human genes:w:wars|WARS]]|0.417|
|[[:human genes:c:c14orf80|C14orf80]]|0.417|
|[[:human genes:d:dctn6|DCTN6]]|0.416|
|[[:human genes:s:ssbp2|SSBP2]]|0.416|
|[[:human genes:c:ccdc115|CCDC115]]|0.416|
|[[:human genes:m:max|MAX]]|0.414|
|[[:human genes:u:uba5|UBA5]]|0.414|
|[[:human genes:f:fbxo11|FBXO11]]|0.413|
|[[:human genes:t:tcf4|TCF4]]|0.413|
|[[:human genes:g:gtf3c5|GTF3C5]]|0.413|
|[[:human genes:t:tceb3|TCEB3]]|0.412|
|[[:human genes:i:id3|ID3]]|0.412|
|[[:human genes:s:spcs3|SPCS3]]|0.411|
|[[:human genes:m:manf|MANF]]|0.411|
|[[:human genes:c:cycs|CYCS]]|0.411|
|[[:human genes:s:serf2|SERF2]]|0.411|
|[[:human genes:k:kdm8|KDM8]]|0.41|
|[[:human genes:a:atf7ip|ATF7IP]]|0.409|
|[[:human genes:u:ubqln1|UBQLN1]]|0.409|
|[[:human genes:r:rpusd4|RPUSD4]]|0.408|
|[[:human genes:c:c15orf41|C15orf41]]|0.407|
|[[:human genes:p:pax5|PAX5]]|0.407|
|[[:human genes:m:maml1|MAML1]]|0.406|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.405|
|[[:human genes:p:ptdss1|PTDSS1]]|0.405|
|[[:human genes:d:derl1|DERL1]]|0.404|
|[[:human genes:z:zzz3|ZZZ3]]|0.404|
|[[:human genes:n:nbn|NBN]]|0.403|
|[[:human genes:c:cars|CARS]]|0.403|
|[[:human genes:z:zfx|ZFX]]|0.403|
|[[:human genes:s:seh1l|SEH1L]]|0.402|
|[[:human genes:t:tomm40|TOMM40]]|0.402|
|[[:human genes:r:rad50|RAD50]]|0.401|
|[[:human genes:v:vps26a|VPS26A]]|0.401|
|[[:human genes:t:trim28|TRIM28]]|0.401|
|[[:human genes:f:fen1|FEN1]]|0.401|
|[[:human genes:m:mrps34|MRPS34]]|0.4|
|[[:human genes:c:c14orf166|C14orf166]]|0.4|
|[[:human genes:t:timm10|TIMM10]]|0.4|
|[[:human genes:m:mrps26|MRPS26]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 730/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|27/28|
|bone|26/26|
|breast|30/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|15/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|15/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 267
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DPAGT1 Expression in NALM6 Cells: 5.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>