DPY30 [The Human Chemical-Genetic Interaction Map Project]

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======= DPY30 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DPY30
  * **<color #00a2e8>Official Name</color>**: dpy-30 histone methyltransferase complex regulatory subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84661|84661]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9C005|Q9C005]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DPY30&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DPY30|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612032|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport. {ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:19651892, ECO:0000269|PubMed:21335234}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Dpy-30|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Set1C/COMPASS complex|
|MLL3/4 complex|
|histone H3-K4 methylation|
|histone methyltransferase complex|
|regulation of megakaryocyte differentiation|
|histone lysine methylation|
|peptidyl-lysine methylation|
|histone methylation|
|protein methylation|
|protein alkylation|
|trans-Golgi network|
|regulation of myeloid cell differentiation|
|endosomal transport|
|macromolecule methylation|
|methylation|
|peptidyl-lysine modification|
|histone modification|
|covalent chromatin modification|
|regulation of hemopoiesis|
|chromatin organization|
|protein homodimerization activity|
|peptidyl-amino acid modification|
|Golgi apparatus|
|chromosome organization|
|identical protein binding|
|intracellular transport|
|regulation of immune system process|
|regulation of cell differentiation|
|establishment of localization in cell|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|-2.26|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|-1.82|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 792
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DPY30 Expression in NALM6 Cells: 5.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>