DPYD [The Human Chemical-Genetic Interaction Map Project]

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======= DPYD =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DPYD
  * **<color #00a2e8>Official Name</color>**: dihydropyrimidine dehydrogenase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1806|1806]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12882|Q12882]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DPYD&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DPYD|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612779|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Dus|
|DHO dh|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dihydropyrimidine dehydrogenase (NADP+) activity|
|pyrimidine deoxyribonucleoside catabolic process|
|thymidine catabolic process|
|beta-alanine biosynthetic process|
|uracil catabolic process|
|uracil binding|
|thymine catabolic process|
|thymine metabolic process|
|uracil metabolic process|
|deoxyribonucleoside catabolic process|
|purine nucleobase catabolic process|
|beta-alanine metabolic process|
|thymidine metabolic process|
|pyrimidine deoxyribonucleoside metabolic process|
|iron-sulfur cluster binding|
|pyrimidine nucleobase catabolic process|
|deoxyribonucleoside metabolic process|
|nucleobase catabolic process|
|purine nucleobase metabolic process|
|pyrimidine nucleobase metabolic process|
|pyrimidine nucleoside catabolic process|
|nucleoside catabolic process|
|pyrimidine nucleoside metabolic process|
|NADP binding|
|4 iron, 4 sulfur cluster binding|
|nucleobase metabolic process|
|neurotransmitter biosynthetic process|
|pyrimidine-containing compound catabolic process|
|glycosyl compound catabolic process|
|nucleobase-containing small molecule catabolic process|
|purine-containing compound catabolic process|
|flavin adenine dinucleotide binding|
|cellular amino acid biosynthetic process|
|neurotransmitter metabolic process|
|pyrimidine-containing compound metabolic process|
|nucleoside metabolic process|
|glycosyl compound metabolic process|
|drug catabolic process|
|carbohydrate derivative catabolic process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|cellular amino acid metabolic process|
|regulation of neurotransmitter levels|
|purine-containing compound metabolic process|
|nucleobase-containing compound catabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|small molecule catabolic process|
|aromatic compound catabolic process|
|organic cyclic compound catabolic process|
|drug metabolic process|
|nucleobase-containing small molecule metabolic process|
|small molecule biosynthetic process|
|protein homodimerization activity|
|carboxylic acid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|organonitrogen compound catabolic process|
|organonitrogen compound biosynthetic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|-2.26|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-1.97|
|[[:results:exp169|BH1 1μM R04 exp169]]|1.7|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|1.7|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|2.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18590
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.63 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DPYD Expression in NALM6 Cells: 0.63'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>