DSCAM [The Human Chemical-Genetic Interaction Map Project]

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======= DSCAM =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DSCAM
  * **<color #00a2e8>Official Name</color>**: DS cell adhesion molecule
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1826|1826]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60469|O60469]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DSCAM&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DSCAM|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602523|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies (PubMed:10925149). Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. In spinal chord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding (PubMed:18585357, PubMed:19196994). Enhances netrin-induced phosphorylation of PAK1 and FYN (PubMed:15169762). Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38 (PubMed:18585357, PubMed:19196994). Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity). {ECO:0000250|UniProtKB:F1NY98, ECO:0000269|PubMed:10925149, ECO:0000269|PubMed:15169762, ECO:0000269|PubMed:18585357, ECO:0000269|PubMed:19196994}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|fn3|
|ig|
|I-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|post-embryonic retina morphogenesis in camera-type eye|
|netrin receptor binding|
|positive regulation of axon extension involved in axon guidance|
|positive regulation of axon guidance|
|netrin-activated signaling pathway|
|post-embryonic animal morphogenesis|
|dendrite self-avoidance|
|camera-type eye photoreceptor cell differentiation|
|cell-cell adhesion mediator activity|
|retina layer formation|
|protein tyrosine kinase binding|
|regulation of axon extension involved in axon guidance|
|positive regulation of axon extension|
|regulation of axon guidance|
|eye photoreceptor cell differentiation|
|neuron recognition|
|retina morphogenesis in camera-type eye|
|neural retina development|
|photoreceptor cell differentiation|
|dendrite morphogenesis|
|positive regulation of axonogenesis|
|post-embryonic development|
|synapse assembly|
|regulation of axon extension|
|dendrite development|
|regulation of extent of cell growth|
|camera-type eye morphogenesis|
|growth cone|
|positive regulation of chemotaxis|
|retina development in camera-type eye|
|eye morphogenesis|
|positive regulation of cell morphogenesis involved in differentiation|
|positive regulation of cell growth|
|homophilic cell adhesion via plasma membrane adhesion molecules|
|positive regulation of developmental growth|
|regulation of cell size|
|regulation of axonogenesis|
|locomotory behavior|
|regulation of chemotaxis|
|cell recognition|
|sensory organ morphogenesis|
|positive regulation of growth|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|axon guidance|
|neuron projection guidance|
|synapse|
|synapse organization|
|negative regulation of cell adhesion|
|positive regulation of neuron projection development|
|axon|
|regulation of cell morphogenesis involved in differentiation|
|camera-type eye development|
|regulation of developmental growth|
|eye development|
|visual system development|
|sensory system development|
|positive regulation of neuron differentiation|
|axonogenesis|
|neuronal cell body|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|axon development|
|regulation of cell growth|
|dendrite|
|cell morphogenesis involved in neuron differentiation|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|cell-cell adhesion|
|regulation of anatomical structure size|
|cell part morphogenesis|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|positive regulation of cell development|
|sensory organ development|
|cell junction|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|cell morphogenesis involved in differentiation|
|behavior|
|positive regulation of response to external stimulus|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of growth|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|cell morphogenesis|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|anatomical structure formation involved in morphogenesis|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|regulation of locomotion|
|regulation of cellular component movement|
|neuron differentiation|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|regulation of response to external stimulus|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|cell projection organization|
|positive regulation of cellular component organization|
|locomotion|
|positive regulation of developmental process|
|integral component of plasma membrane|
|generation of neurons|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|neurogenesis|
|cell development|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|extracellular region|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-2.74|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|1.75|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|1.75|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|1.97|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|2|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.44|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17899
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DSCAM Expression in NALM6 Cells: -1.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>