DST [The Human Chemical-Genetic Interaction Map Project]

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======= DST =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DST
  * **<color #00a2e8>Official Name</color>**: dystonin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=667|667]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q03001|Q03001]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DST&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DST|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/113810|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the plakin protein family of adhesion junction plaque proteins. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the full-length nature of some variants has not been defined. It has been reported that some isoforms are expressed in neural and muscle tissue, anchoring neural intermediate filaments to the actin cytoskeleton, and some isoforms are expressed in epithelial tissue, anchoring keratin-containing intermediate filaments to hemidesmosomes. Consistent with the expression, mice defective for this gene show skin blistering and neurodegeneration. [provided by RefSeq, Mar 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Plectin|
|GAS2|
|CH|
|Spectrin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|H zone|
|hemidesmosome|
|hemidesmosome assembly|
|maintenance of cell polarity|
|microtubule plus-end binding|
|retrograde axonal transport|
|microtubule plus-end|
|basal plasma membrane|
|cell leading edge|
|cell-substrate junction assembly|
|intermediate filament cytoskeleton organization|
|intermediate filament-based process|
|cytoplasmic microtubule organization|
|axonal transport|
|axon cytoplasm|
|axo-dendritic transport|
|basement membrane|
|integrin-mediated signaling pathway|
|intermediate filament|
|integrin binding|
|Z disc|
|cell cortex|
|microtubule cytoskeleton|
|transport along microtubule|
|cell junction assembly|
|cytoskeleton-dependent intracellular transport|
|nuclear envelope|
|microtubule-based transport|
|protein C-terminus binding|
|structural molecule activity|
|establishment or maintenance of cell polarity|
|cell junction organization|
|microtubule binding|
|cytoplasmic vesicle|
|actin binding|
|microtubule-based movement|
|focal adhesion|
|supramolecular fiber organization|
|microtubule cytoskeleton organization|
|wound healing|
|response to wounding|
|microtubule-based process|
|calcium ion binding|
|cell adhesion|
|biological adhesion|
|endoplasmic reticulum membrane|
|cell motility|
|localization of cell|
|cytoskeleton organization|
|locomotion|
|intracellular transport|
|movement of cell or subcellular component|
|establishment of localization in cell|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|1.8|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|1.82|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.96|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|1.97|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|1.98|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|2.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3498
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DST Expression in NALM6 Cells: 0.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>