DTL [The Human Chemical-Genetic Interaction Map Project]

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======= DTL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DTL
  * **<color #00a2e8>Official Name</color>**: denticleless E3 ubiquitin protein ligase homolog
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51514|51514]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NZJ0|Q9NZJ0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DTL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DTL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610617|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBXO18/FBH1, KMT5A and SDE2 (PubMed:16861906, PubMed:16949367, PubMed:16964240, PubMed:17085480, PubMed:18703516, PubMed:18794347, PubMed:18794348, PubMed:19332548, PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613, PubMed:27906959). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication (PubMed:16861906, PubMed:16949367, PubMed:17085480). CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing (PubMed:18794348, PubMed:19332548). KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration (PubMed:23478445). Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA- dependent translesion DNA synthesis (PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613). {ECO:0000269|PubMed:16861906, ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:17085480, ECO:0000269|PubMed:18703516, ECO:0000269|PubMed:18794347, ECO:0000269|PubMed:18794348, ECO:0000269|PubMed:19332548, ECO:0000269|PubMed:20129063, ECO:0000269|PubMed:23478441, ECO:0000269|PubMed:23478445, ECO:0000269|PubMed:23677613, ECO:0000269|PubMed:27906959}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Cul4B-RING E3 ubiquitin ligase complex|
|Cul4A-RING E3 ubiquitin ligase complex|
|signal transduction involved in G2 DNA damage checkpoint|
|Cul4-RING E3 ubiquitin ligase complex|
|positive regulation of G2/M transition of mitotic cell cycle|
|G2 DNA damage checkpoint|
|positive regulation of cell cycle G2/M phase transition|
|DNA damage response, detection of DNA damage|
|translesion synthesis|
|DNA synthesis involved in DNA repair|
|postreplication repair|
|protein monoubiquitination|
|signal transduction involved in DNA damage checkpoint|
|signal transduction involved in DNA integrity checkpoint|
|signal transduction involved in cell cycle checkpoint|
|positive regulation of mitotic cell cycle phase transition|
|positive regulation of cell cycle phase transition|
|negative regulation of cell cycle G2/M phase transition|
|signal transduction in response to DNA damage|
|DNA biosynthetic process|
|chromosome|
|DNA damage checkpoint|
|response to UV|
|DNA integrity checkpoint|
|positive regulation of mitotic cell cycle|
|cell cycle checkpoint|
|regulation of G2/M transition of mitotic cell cycle|
|regulation of cell cycle G2/M phase transition|
|DNA replication|
|positive regulation of protein catabolic process|
|negative regulation of cell cycle phase transition|
|nuclear membrane|
|ubiquitin-protein transferase activity|
|rhythmic process|
|positive regulation of cell cycle process|
|protein polyubiquitination|
|response to light stimulus|
|negative regulation of cell cycle process|
|post-translational protein modification|
|positive regulation of cell cycle|
|regulation of protein catabolic process|
|regulation of mitotic cell cycle phase transition|
|positive regulation of catabolic process|
|response to radiation|
|regulation of cell cycle phase transition|
|centrosome|
|DNA repair|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|negative regulation of cell cycle|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|regulation of mitotic cell cycle|
|protein catabolic process|
|protein ubiquitination|
|detection of stimulus|
|DNA metabolic process|
|regulation of cell cycle process|
|protein modification by small protein conjugation|
|cellular response to DNA damage stimulus|
|nucleolus|
|cellular macromolecule catabolic process|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|nucleobase-containing compound biosynthetic process|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|proteolysis|
|organic cyclic compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.99|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-1.86|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|-1.73|
|[[:results:exp11|CCCP 1μM R00 exp11]]|1.71|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.75|
|[[:results:exp16|DABN 2μM R00 exp16]]|1.76|
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|1.85|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|1.86|
|[[:results:exp331|A-769662 20μM R07 exp331]]|1.88|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|1.9|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|1.95|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|1.98|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|2.02|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|2.07|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|2.18|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|2.23|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|2.41|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|2.49|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|2.52|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|2.68|
|[[:results:exp224|CB-839 10μM R05 exp224]]|2.69|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|2.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.614|
|[[:human genes:p:psmc1|PSMC1]]|0.576|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.576|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.571|
|[[:human genes:p:psma6|PSMA6]]|0.567|
|[[:human genes:s:sec13|SEC13]]|0.567|
|[[:human genes:c:cbwd3|CBWD3]]|0.562|
|[[:human genes:c:copg1|COPG1]]|0.56|
|[[:human genes:p:pan3|PAN3]]|0.549|
|[[:human genes:t:tceb3c|TCEB3C]]|0.548|
|[[:human genes:s:ssh2|SSH2]]|0.546|
|[[:human genes:s:supt6h|SUPT6H]]|0.546|
|[[:human genes:c:c14orf93|C14orf93]]|0.545|
|[[:human genes:n:nupl1|NUPL1]]|0.542|
|[[:human genes:s:sf3a3|SF3A3]]|0.542|
|[[:human genes:c:cbwd5|CBWD5]]|0.538|
|[[:human genes:v:vasn|VASN]]|0.538|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.538|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.535|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.535|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.534|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.534|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.534|
|[[:human genes:o:orc6|ORC6]]|0.532|
|[[:human genes:c:cbwd6|CBWD6]]|0.531|
|[[:human genes:z:znf106|ZNF106]]|0.53|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.527|
|[[:human genes:r:rpl35|RPL35]]|0.525|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.522|
|[[:human genes:n:nup160|NUP160]]|0.522|
|[[:human genes:r:rps2|RPS2]]|0.519|
|[[:human genes:t:ticrr|TICRR]]|0.518|
|[[:human genes:t:tyms|TYMS]]|0.518|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.518|
|[[:human genes:a:aamp|AAMP]]|0.517|
|[[:human genes:w:wdr87|WDR87]]|0.516|
|[[:human genes:r:rps12|RPS12]]|0.516|
|[[:human genes:p:psmb1|PSMB1]]|0.515|
|[[:human genes:c:chd4|CHD4]]|0.513|
|[[:human genes:m:myo1h|MYO1H]]|0.511|
|[[:human genes:n:npipb5|NPIPB5]]|0.508|
|[[:human genes:p:psmb4|PSMB4]]|0.506|
|[[:human genes:c:ccna2|CCNA2]]|0.506|
|[[:human genes:t:twistnb|TWISTNB]]|0.505|
|[[:human genes:a:ahctf1|AHCTF1]]|0.505|
|[[:human genes:d:ddtl|DDTL]]|0.504|
|[[:human genes:s:supt5h|SUPT5H]]|0.503|
|[[:human genes:c:cdc73|CDC73]]|0.503|
|[[:human genes:m:mt1e|MT1E]]|0.502|
|[[:human genes:r:ranbp2|RANBP2]]|0.501|
|[[:human genes:p:psmb2|PSMB2]]|0.5|
|[[:human genes:n:narfl|NARFL]]|0.5|
|[[:human genes:s:snrpa1|SNRPA1]]|0.498|
|[[:human genes:a:aqr|AQR]]|0.497|
|[[:human genes:n:nup153|NUP153]]|0.496|
|[[:human genes:n:nol10|NOL10]]|0.496|
|[[:human genes:z:znf655|ZNF655]]|0.496|
|[[:human genes:p:psmd2|PSMD2]]|0.496|
|[[:human genes:a:acsf2|ACSF2]]|0.495|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.495|
|[[:human genes:t:tfip11|TFIP11]]|0.494|
|[[:human genes:k:kpnb1|KPNB1]]|0.492|
|[[:human genes:r:rrn3|RRN3]]|0.492|
|[[:human genes:a:akirin2|AKIRIN2]]|0.491|
|[[:human genes:k:kctd17|KCTD17]]|0.49|
|[[:human genes:p:prpf8|PRPF8]]|0.49|
|[[:human genes:z:zfand5|ZFAND5]]|0.489|
|[[:human genes:u:utp3|UTP3]]|0.488|
|[[:human genes:p:psmc2|PSMC2]]|0.488|
|[[:human genes:r:rbm39|RBM39]]|0.487|
|[[:human genes:c:cln6|CLN6]]|0.486|
|[[:human genes:c:clasp1|CLASP1]]|0.486|
|[[:human genes:c:cep192|CEP192]]|0.485|
|[[:human genes:r:rrp7a|RRP7A]]|0.484|
|[[:human genes:r:rad51|RAD51]]|0.482|
|[[:human genes:c:cdc6|CDC6]]|0.481|
|[[:human genes:m:madcam1|MADCAM1]]|0.48|
|[[:human genes:r:rpl14|RPL14]]|0.48|
|[[:human genes:n:ndc80|NDC80]]|0.479|
|[[:human genes:c:copz1|COPZ1]]|0.478|
|[[:human genes:e:exosc3|EXOSC3]]|0.476|
|[[:human genes:s:syt9|SYT9]]|0.476|
|[[:human genes:m:med17|MED17]]|0.476|
|[[:human genes:p:polr2j3|POLR2J3]]|0.475|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.475|
|[[:human genes:d:ddx56|DDX56]]|0.474|
|[[:human genes:p:psmc3|PSMC3]]|0.474|
|[[:human genes:c:copb2|COPB2]]|0.474|
|[[:human genes:s:snip1|SNIP1]]|0.474|
|[[:human genes:p:psmc6|PSMC6]]|0.473|
|[[:human genes:p:psmd11|PSMD11]]|0.473|
|[[:human genes:s:slc4a1|SLC4A1]]|0.473|
|[[:human genes:r:rpl6|RPL6]]|0.473|
|[[:human genes:p:psmd14|PSMD14]]|0.473|
|[[:human genes:p:psmd1|PSMD1]]|0.47|
|[[:human genes:p:pole|POLE]]|0.47|
|[[:human genes:s:slc6a17|SLC6A17]]|0.47|
|[[:human genes:f:fam160a1|FAM160A1]]|0.47|
|[[:human genes:p:plk1|PLK1]]|0.469|
|[[:human genes:e:exosc9|EXOSC9]]|0.469|
|[[:human genes:g:golga8j|GOLGA8J]]|0.469|
|[[:human genes:c:cdca3|CDCA3]]|0.468|
|[[:human genes:r:rpa2|RPA2]]|0.468|
|[[:human genes:c:copb1|COPB1]]|0.467|
|[[:human genes:m:mfsd12|MFSD12]]|0.467|
|[[:human genes:p:psmd3|PSMD3]]|0.466|
|[[:human genes:p:pla2g4f|PLA2G4F]]|0.465|
|[[:human genes:u:uqcrh|UQCRH]]|0.463|
|[[:human genes:g:gosr2|GOSR2]]|0.462|
|[[:human genes:a:ankle2|ANKLE2]]|0.462|
|[[:human genes:z:znf830|ZNF830]]|0.462|
|[[:human genes:x:xylt2|XYLT2]]|0.462|
|[[:human genes:w:wdr43|WDR43]]|0.462|
|[[:human genes:n:nop16|NOP16]]|0.462|
|[[:human genes:o:orc1|ORC1]]|0.462|
|[[:human genes:r:rbbp5|RBBP5]]|0.462|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.461|
|[[:human genes:s:smg7|SMG7]]|0.461|
|[[:human genes:c:crnkl1|CRNKL1]]|0.46|
|[[:human genes:s:s1pr4|S1PR4]]|0.46|
|[[:human genes:l:lrr1|LRR1]]|0.46|
|[[:human genes:g:gar1|GAR1]]|0.459|
|[[:human genes:v:vps54|VPS54]]|0.459|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.456|
|[[:human genes:t:tsg101|TSG101]]|0.456|
|[[:human genes:p:plekha4|PLEKHA4]]|0.455|
|[[:human genes:p:psmc4|PSMC4]]|0.455|
|[[:human genes:d:disp2|DISP2]]|0.455|
|[[:human genes:n:napa|NAPA]]|0.454|
|[[:human genes:a:aatf|AATF]]|0.454|
|[[:human genes:z:znf574|ZNF574]]|0.454|
|[[:human genes:s:sult2b1|SULT2B1]]|0.453|
|[[:human genes:c:ctr9|CTR9]]|0.453|
|[[:human genes:t:timeless|TIMELESS]]|0.453|
|[[:human genes:m:msh5|MSH5]]|0.453|
|[[:human genes:a:ankle1|ANKLE1]]|0.452|
|[[:human genes:r:rrp15|RRP15]]|0.452|
|[[:human genes:f:fbxw9|FBXW9]]|0.451|
|[[:human genes:u:utp20|UTP20]]|0.45|
|[[:human genes:r:rps28|RPS28]]|0.449|
|[[:human genes:t:tagln|TAGLN]]|0.449|
|[[:human genes:r:rpsa|RPSA]]|0.449|
|[[:human genes:s:srgap2c|SRGAP2C]]|0.449|
|[[:human genes:a:aaas|AAAS]]|0.448|
|[[:human genes:r:rps3|RPS3]]|0.448|
|[[:human genes:t:terf1|TERF1]]|0.448|
|[[:human genes:p:psma7|PSMA7]]|0.448|
|[[:human genes:e:eif4a3|EIF4A3]]|0.447|
|[[:human genes:d:dock6|DOCK6]]|0.447|
|[[:human genes:p:psmd8|PSMD8]]|0.447|
|[[:human genes:c:chaf1a|CHAF1A]]|0.446|
|[[:human genes:c:cope|COPE]]|0.446|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.446|
|[[:human genes:g:golga6a|GOLGA6A]]|0.446|
|[[:human genes:v:vps28|VPS28]]|0.445|
|[[:human genes:p:pcf11|PCF11]]|0.445|
|[[:human genes:p:pola2|POLA2]]|0.445|
|[[:human genes:s:sf3a2|SF3A2]]|0.445|
|[[:human genes:p:polr1a|POLR1A]]|0.445|
|[[:human genes:p:pan2|PAN2]]|0.445|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.444|
|[[:human genes:n:nup85|NUP85]]|0.443|
|[[:human genes:m:med12|MED12]]|0.443|
|[[:human genes:d:dhx38|DHX38]]|0.442|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.442|
|[[:human genes:p:polr2a|POLR2A]]|0.441|
|[[:human genes:t:tuba8|TUBA8]]|0.441|
|[[:human genes:h:hap1|HAP1]]|0.44|
|[[:human genes:r:rad21|RAD21]]|0.44|
|[[:human genes:g:gid4|GID4]]|0.439|
|[[:human genes:a:abt1|ABT1]]|0.439|
|[[:human genes:r:rps3a|RPS3A]]|0.439|
|[[:human genes:m:mat2a|MAT2A]]|0.439|
|[[:human genes:c:col2a1|COL2A1]]|0.437|
|[[:human genes:c:ctage4|CTAGE4]]|0.437|
|[[:human genes:c:chmp2a|CHMP2A]]|0.437|
|[[:human genes:m:med14|MED14]]|0.437|
|[[:human genes:g:gbf1|GBF1]]|0.435|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.435|
|[[:human genes:m:mcoln1|MCOLN1]]|0.435|
|[[:human genes:s:smg1|SMG1]]|0.435|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.435|
|[[:human genes:i:ik|IK]]|0.434|
|[[:human genes:n:nup43|NUP43]]|0.434|
|[[:human genes:r:rpl9|RPL9]]|0.434|
|[[:human genes:p:psmc5|PSMC5]]|0.433|
|[[:human genes:n:nol12|NOL12]]|0.433|
|[[:human genes:c:c2orf27b|C2orf27B]]|0.431|
|[[:human genes:w:wdr75|WDR75]]|0.431|
|[[:human genes:c:copa|COPA]]|0.431|
|[[:human genes:n:nfatc4|NFATC4]]|0.431|
|[[:human genes:p:paf1|PAF1]]|0.431|
|[[:human genes:a:atp6ap1|ATP6AP1]]|0.428|
|[[:human genes:a:atxn1|ATXN1]]|0.428|
|[[:human genes:r:rrp1|RRP1]]|0.427|
|[[:human genes:p:polr2d|POLR2D]]|0.427|
|[[:human genes:r:rnf113a|RNF113A]]|0.427|
|[[:human genes:r:rfxank|RFXANK]]|0.426|
|[[:human genes:p:prpf3|PRPF3]]|0.425|
|[[:human genes:a:atp13a1|ATP13A1]]|0.425|
|[[:human genes:p:ppm1d|PPM1D]]|0.425|
|[[:human genes:c:cdt1|CDT1]]|0.425|
|[[:human genes:s:scaf1|SCAF1]]|0.425|
|[[:human genes:c:chmp4b|CHMP4B]]|0.424|
|[[:human genes:l:loc643669|LOC643669]]|0.424|
|[[:human genes:s:sf3a1|SF3A1]]|0.424|
|[[:human genes:m:mms22l|MMS22L]]|0.424|
|[[:human genes:t:top1mt|TOP1MT]]|0.423|
|[[:human genes:o:or10g3|OR10G3]]|0.422|
|[[:human genes:t:tspy8|TSPY8]]|0.421|
|[[:human genes:u:usp36|USP36]]|0.421|
|[[:human genes:u:ubl5|UBL5]]|0.421|
|[[:human genes:c:cdh24|CDH24]]|0.42|
|[[:human genes:p:psmd7|PSMD7]]|0.42|
|[[:human genes:d:ddt|DDT]]|0.42|
|[[:human genes:c:cactin|CACTIN]]|0.419|
|[[:human genes:i:itga2b|ITGA2B]]|0.418|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.418|
|[[:human genes:r:rpl7l1|RPL7L1]]|0.417|
|[[:human genes:n:nup133|NUP133]]|0.417|
|[[:human genes:s:slc38a7|SLC38A7]]|0.416|
|[[:human genes:r:rpl26|RPL26]]|0.416|
|[[:human genes:h:hivep3|HIVEP3]]|0.416|
|[[:human genes:k:kif3c|KIF3C]]|0.415|
|[[:human genes:t:tspy1|TSPY1]]|0.415|
|[[:human genes:t:terf2|TERF2]]|0.414|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.414|
|[[:human genes:i:ints5|INTS5]]|0.413|
|[[:human genes:s:sap30bp|SAP30BP]]|0.413|
|[[:human genes:o:ogfr|OGFR]]|0.412|
|[[:human genes:f:fcn2|FCN2]]|0.412|
|[[:human genes:t:tipin|TIPIN]]|0.412|
|[[:human genes:m:mcm10|MCM10]]|0.412|
|[[:human genes:n:nbpf10|NBPF10]]|0.412|
|[[:human genes:g:gprin2|GPRIN2]]|0.411|
|[[:human genes:g:gltscr2|GLTSCR2]]|0.411|
|[[:human genes:p:polr2f|POLR2F]]|0.411|
|[[:human genes:t:traip|TRAIP]]|0.41|
|[[:human genes:s:snx15|SNX15]]|0.41|
|[[:human genes:d:dido1|DIDO1]]|0.409|
|[[:human genes:u:upf1|UPF1]]|0.408|
|[[:human genes:g:golga8k|GOLGA8K]]|0.408|
|[[:human genes:i:igfn1|IGFN1]]|0.408|
|[[:human genes:n:nbpf16|NBPF16]]|0.408|
|[[:human genes:n:nufip2|NUFIP2]]|0.408|
|[[:human genes:n:nup205|NUP205]]|0.408|
|[[:human genes:p:phf2|PHF2]]|0.407|
|[[:human genes:h:hmgcr|HMGCR]]|0.407|
|[[:human genes:p:parp3|PARP3]]|0.406|
|[[:human genes:m:myt1l|MYT1L]]|0.406|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.406|
|[[:human genes:l:lrrc56|LRRC56]]|0.405|
|[[:human genes:c:cox7a2l|COX7A2L]]|0.405|
|[[:human genes:m:mylk3|MYLK3]]|0.405|
|[[:human genes:a:arhgef35|ARHGEF35]]|0.404|
|[[:human genes:p:psmb3|PSMB3]]|0.404|
|[[:human genes:c:ciapin1|CIAPIN1]]|0.404|
|[[:human genes:r:rps9|RPS9]]|0.404|
|[[:human genes:n:numa1|NUMA1]]|0.404|
|[[:human genes:c:cdc45|CDC45]]|0.403|
|[[:human genes:p:pigs|PIGS]]|0.403|
|[[:human genes:b:brd2|BRD2]]|0.403|
|[[:human genes:c:ccdc116|CCDC116]]|0.403|
|[[:human genes:r:rpl8|RPL8]]|0.402|
|[[:human genes:p:pbxip1|PBXIP1]]|0.402|
|[[:human genes:r:rps19|RPS19]]|0.402|
|[[:human genes:a:add2|ADD2]]|0.402|
|[[:human genes:p:pold1|POLD1]]|0.401|
|[[:human genes:c:cgb2|CGB2]]|0.401|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.401|
|[[:human genes:c:cnot1|CNOT1]]|0.401|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.401|
|[[:human genes:e:exosc5|EXOSC5]]|0.401|
|[[:human genes:s:sfpq|SFPQ]]|0.401|
|[[:human genes:g:gpt|GPT]]|0.4|
|[[:human genes:t:trim52|TRIM52]]|0.4|
|[[:human genes:u:ubap1|UBAP1]]|0.4|
|[[:human genes:a:adra1d|ADRA1D]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 733/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|32/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|19/20|
|lung|74/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 746
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DTL Expression in NALM6 Cells: 6.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>