DYNC1I2 [The Human Chemical-Genetic Interaction Map Project]

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======= DYNC1I2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DYNC1I2
  * **<color #00a2e8>Official Name</color>**: dynein cytoplasmic 1 intermediate chain 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1781|1781]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13409|Q13409]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DYNC1I2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DYNC1I2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603331|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Dynein IC2|
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dynein heavy chain binding|
|cytoplasmic dynein complex|
|dynein light chain binding|
|ATP-dependent microtubule motor activity, plus-end-directed|
|microtubule motor activity|
|ciliary basal body-plasma membrane docking|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|antigen processing and presentation of peptide antigen via MHC class II|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|vesicle|
|organelle localization by membrane tethering|
|antigen processing and presentation of exogenous peptide antigen|
|membrane docking|
|antigen processing and presentation of exogenous antigen|
|antigen processing and presentation of peptide antigen|
|regulation of G2/M transition of mitotic cell cycle|
|regulation of cell cycle G2/M phase transition|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|antigen processing and presentation|
|mitotic cell cycle phase transition|
|microtubule-based movement|
|cell cycle phase transition|
|microtubule|
|cilium assembly|
|cilium organization|
|Golgi vesicle transport|
|regulation of mitotic cell cycle phase transition|
|plasma membrane bounded cell projection assembly|
|regulation of cell cycle phase transition|
|cell projection assembly|
|centrosome|
|organelle localization|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|microtubule-based process|
|mitotic cell cycle|
|viral process|
|regulation of cell cycle process|
|organelle assembly|
|symbiotic process|
|interspecies interaction between organisms|
|cell cycle process|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of cell cycle|
|cell cycle|
|intracellular transport|
|movement of cell or subcellular component|
|establishment of localization in cell|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.76|
|[[:results:exp169|BH1 1μM R04 exp169]]|1.7|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|1.7|
|[[:results:exp218|A-395 10μM R05 exp218]]|1.85|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|1.89|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|2.06|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|2.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nupl1|NUPL1]]|0.46|
|[[:human genes:t:trappc2l|TRAPPC2L]]|0.452|
|[[:human genes:p:psmd1|PSMD1]]|0.445|
|[[:human genes:p:psmd3|PSMD3]]|0.443|
|[[:human genes:s:sfpq|SFPQ]]|0.44|
|[[:human genes:e:elmod3|ELMOD3]]|0.439|
|[[:human genes:r:rad21|RAD21]]|0.439|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.438|
|[[:human genes:v:vasn|VASN]]|0.437|
|[[:human genes:z:znf106|ZNF106]]|0.434|
|[[:human genes:o:ogfr|OGFR]]|0.42|
|[[:human genes:s:ssh2|SSH2]]|0.418|
|[[:human genes:s:supt6h|SUPT6H]]|0.417|
|[[:human genes:m:med17|MED17]]|0.417|
|[[:human genes:p:psmc1|PSMC1]]|0.415|
|[[:human genes:t:twistnb|TWISTNB]]|0.412|
|[[:human genes:g:gbf1|GBF1]]|0.408|
|[[:human genes:z:zfand5|ZFAND5]]|0.406|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.406|
|[[:human genes:p:psmc2|PSMC2]]|0.405|
|[[:human genes:b:bcl2l1|BCL2L1]]|0.404|
|[[:human genes:f:fbxo5|FBXO5]]|0.403|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.402|
|[[:human genes:s:sec13|SEC13]]|0.402|
|[[:human genes:c:cbwd5|CBWD5]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 704/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|25/28|
|bone|25/26|
|breast|32/33|
|central nervous system|54/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|18/21|
|liver|20/20|
|lung|70/75|
|lymphocyte|15/16|
|ovary|23/26|
|pancreas|24/24|
|peripheral nervous system|15/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|22/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|27/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1338
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DYNC1I2 Expression in NALM6 Cells: 6.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>