DYNC2LI1 [The Human Chemical-Genetic Interaction Map Project]

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======= DYNC2LI1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DYNC2LI1
  * **<color #00a2e8>Official Name</color>**: dynein cytoplasmic 2 light intermediate chain 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51626|51626]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TCX1|Q8TCX1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DYNC2LI1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DYNC2LI1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617083|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that is a component of the dynein-2 microtubule motor protein complex that plays a role in the retrograde transport of cargo in primary cilia via the intraflagellar transport system. This gene is ubiquitously expressed and its protein, which localizes to the axoneme and Golgi apparatus, interacts directly with the cytoplasmic dynein 2 heavy chain 1 protein to form part of the multi-protein dynein-2 complex. Mutations in this gene produce defects in the dynein-2 complex which result in several types of ciliopathy including short-rib thoracic dysplasia 15 with polydactyly (SRTD15). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DLIC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|intraciliary transport particle|
|intraciliary retrograde transport|
|dynein heavy chain binding|
|ATP-dependent microtubule motor activity, minus-end-directed|
|cytoplasmic dynein complex|
|ciliary transition zone|
|intraciliary transport involved in cilium assembly|
|ciliary tip|
|intraciliary transport|
|cytoplasmic microtubule|
|microtubule-based protein transport|
|protein transport along microtubule|
|apical part of cell|
|regulation of cilium assembly|
|motile cilium|
|axoneme|
|determination of left/right symmetry|
|determination of bilateral symmetry|
|specification of symmetry|
|ciliary basal body|
|transport along microtubule|
|cytoskeleton-dependent intracellular transport|
|microtubule-based transport|
|cilium|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|regulation of organelle assembly|
|protein-containing complex localization|
|microtubule-based movement|
|cilium assembly|
|cilium organization|
|pattern specification process|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|centrosome|
|microtubule-based process|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|organelle assembly|
|regulation of cellular component biogenesis|
|intracellular protein transport|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of organelle organization|
|protein transport|
|intracellular transport|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16033
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DYNC2LI1 Expression in NALM6 Cells: 4.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>