DYNLT1 [The Human Chemical-Genetic Interaction Map Project]

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======= DYNLT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DYNLT1
  * **<color #00a2e8>Official Name</color>**: dynein light chain Tctex-type 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6993|6993]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P63172|P63172]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DYNLT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DYNLT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601554|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. May also be a accessory component of axonemal dynein. (Microbial infection) Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic assembly site. {ECO:0000269|PubMed:18647839}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tctex-1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|microtubule-dependent intracellular transport of viral material towards nucleus|
|transport of viral material towards nucleus|
|microtubule-dependent intracellular transport of viral material|
|intracellular protein transport in other organism involved in symbiotic interaction|
|symbiont intracellular protein transport in host|
|intracellular transport of viral protein in host cell|
|secretory vesicle|
|positive regulation of Rac protein signal transduction|
|negative regulation of mitochondrial membrane permeability|
|regulation by virus of viral protein levels in host cell|
|multi-organism cellular localization|
|multi-organism intracellular transport|
|negative regulation of membrane permeability|
|regulation of Rac protein signal transduction|
|cytoplasmic dynein complex|
|axonal growth cone|
|establishment of mitotic spindle orientation|
|establishment of mitotic spindle localization|
|establishment of spindle orientation|
|establishment of spindle localization|
|motor activity|
|spindle localization|
|cytoplasmic microtubule|
|intracellular transport of virus|
|host cell|
|transport of virus|
|positive regulation of Ras protein signal transduction|
|multi-organism transport|
|multi-organism localization|
|positive regulation of small GTPase mediated signal transduction|
|regulation of mitochondrial membrane permeability|
|regulation of membrane permeability|
|viral entry into host cell|
|entry into host cell|
|dendrite development|
|entry into host|
|microtubule cytoskeleton organization involved in mitosis|
|secretory granule lumen|
|establishment of cell polarity|
|spindle|
|ficolin-1-rich granule lumen|
|mitochondrial membrane organization|
|regulation of G protein-coupled receptor signaling pathway|
|interaction with host|
|lamellipodium|
|protein C-terminus binding|
|establishment or maintenance of cell polarity|
|viral life cycle|
|regulation of viral process|
|mitochondrial transport|
|regulation of symbiosis, encompassing mutualism through parasitism|
|regulation of Ras protein signal transduction|
|positive regulation of neuron projection development|
|negative regulation of neurogenesis|
|negative regulation of nervous system development|
|negative regulation of cell development|
|regulation of small GTPase mediated signal transduction|
|establishment of organelle localization|
|positive regulation of neuron differentiation|
|neuronal cell body|
|positive regulation of cell projection organization|
|axon development|
|mitochondrion organization|
|positive regulation of neurogenesis|
|microtubule cytoskeleton organization|
|neuron projection morphogenesis|
|regulation of GTPase activity|
|plasma membrane bounded cell projection morphogenesis|
|neutrophil degranulation|
|cell projection morphogenesis|
|neutrophil activation involved in immune response|
|cell division|
|regulation of neuron projection development|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|cell part morphogenesis|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|positive regulation of nervous system development|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|organelle localization|
|myeloid leukocyte activation|
|mitotic cell cycle process|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of neuron differentiation|
|neuron projection development|
|microtubule-based process|
|mitotic cell cycle|
|regulation of plasma membrane bounded cell projection organization|
|viral process|
|regulated exocytosis|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|cell morphogenesis|
|leukocyte mediated immunity|
|regulation of multi-organism process|
|symbiotic process|
|exocytosis|
|neuron development|
|regulation of neurogenesis|
|interspecies interaction between organisms|
|cellular component morphogenesis|
|membrane organization|
|regulation of nervous system development|
|leukocyte activation|
|regulation of cell development|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|Golgi apparatus|
|intracellular protein transport|
|negative regulation of cell death|
|cell cycle process|
|secretion by cell|
|neuron differentiation|
|positive regulation of intracellular signal transduction|
|export from cell|
|identical protein binding|
|cell activation|
|immune effector process|
|cytoskeleton organization|
|chemical homeostasis|
|plasma membrane bounded cell projection organization|
|secretion|
|cell projection organization|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|mitochondrion|
|regulation of hydrolase activity|
|regulation of organelle organization|
|cell cycle|
|positive regulation of developmental process|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-2.87|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-2.71|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-2.26|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-2.03|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-1.99|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|-1.97|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-1.88|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-1.82|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12022
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DYNLT1 Expression in NALM6 Cells: 4.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>