E2F2 [The Human Chemical-Genetic Interaction Map Project]

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======= E2F2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: E2F2
  * **<color #00a2e8>Official Name</color>**: E2F transcription factor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1870|1870]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14209|Q14209]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=E2F2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20E2F2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600426|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|E2F TDP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|lens fiber cell apoptotic process|
|negative regulation of sprouting angiogenesis|
|epithelial cell apoptotic process|
|proximal promoter sequence-specific DNA binding|
|intrinsic apoptotic signaling pathway by p53 class mediator|
|regulation of sprouting angiogenesis|
|RNA polymerase II transcription factor complex|
|negative regulation of angiogenesis|
|negative regulation of blood vessel morphogenesis|
|negative regulation of vasculature development|
|signal transduction by p53 class mediator|
|intrinsic apoptotic signaling pathway|
|protein dimerization activity|
|transcription initiation from RNA polymerase II promoter|
|DNA-templated transcription, initiation|
|apoptotic signaling pathway|
|regulation of angiogenesis|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|regulation of vasculature development|
|transcription factor binding|
|sequence-specific DNA binding|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|DNA-binding transcription factor activity|
|negative regulation of transcription by RNA polymerase II|
|apoptotic process|
|negative regulation of developmental process|
|programmed cell death|
|regulation of anatomical structure morphogenesis|
|cell death|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|intracellular signal transduction|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|1.79|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|1.83|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|1.94|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|2.05|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.21|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.38|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.48|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.55|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|2.87|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|3.47|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|3.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tfdp1|TFDP1]]|0.456|
|[[:human genes:c:ctnnbl1|CTNNBL1]]|0.402|
|[[:human genes:u:ube2q1|UBE2Q1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9045
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='E2F2 Expression in NALM6 Cells: 8.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>