EDA [The Human Chemical-Genetic Interaction Map Project]

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======= EDA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EDA
  * **<color #00a2e8>Official Name</color>**: ectodysplasin A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1896|1896]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92838|Q92838]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EDA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EDA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300451|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TNF|
|Collagen|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|trachea submucosa development|
|trachea gland development|
|hair follicle placode formation|
|salivary gland cavitation|
|tube lumen cavitation|
|ectodermal placode formation|
|ectodermal placode morphogenesis|
|ectodermal placode development|
|trachea development|
|salivary gland morphogenesis|
|tumor necrosis factor receptor binding|
|salivary gland development|
|exocrine system development|
|collagen trimer|
|apical part of cell|
|hair follicle development|
|skin epidermis development|
|molting cycle process|
|hair cycle process|
|positive regulation of NIK/NF-kappaB signaling|
|lipid droplet|
|odontogenesis of dentin-containing tooth|
|molting cycle|
|pigmentation|
|hair cycle|
|gland morphogenesis|
|regulation of NIK/NF-kappaB signaling|
|tumor necrosis factor-mediated signaling pathway|
|odontogenesis|
|cell-matrix adhesion|
|positive regulation of canonical Wnt signaling pathway|
|tube formation|
|positive regulation of NF-kappaB transcription factor activity|
|positive regulation of Wnt signaling pathway|
|cell-substrate adhesion|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|respiratory system development|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|cellular response to tumor necrosis factor|
|positive regulation of DNA-binding transcription factor activity|
|response to tumor necrosis factor|
|regulation of canonical Wnt signaling pathway|
|signaling receptor binding|
|regulation of Wnt signaling pathway|
|cytoskeleton|
|skin development|
|gland development|
|epidermis development|
|regulation of DNA-binding transcription factor activity|
|tube morphogenesis|
|cytokine-mediated signaling pathway|
|intracellular membrane-bounded organelle|
|tube development|
|anatomical structure formation involved in morphogenesis|
|cell adhesion|
|biological adhesion|
|endoplasmic reticulum membrane|
|animal organ morphogenesis|
|cellular response to cytokine stimulus|
|positive regulation of intracellular signal transduction|
|response to cytokine|
|epithelium development|
|integral component of plasma membrane|
|positive regulation of signal transduction|
|tissue development|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|immune response|
|extracellular region|
|positive regulation of gene expression|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9641
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EDA Expression in NALM6 Cells: 5.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>