EDN2 [The Human Chemical-Genetic Interaction Map Project]

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======= EDN2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EDN2
  * **<color #00a2e8>Official Name</color>**: endothelin 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1907|1907]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P20800|P20800]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EDN2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EDN2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/131241|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Endothelins are endothelium-derived vasoconstrictor peptides.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Endothelin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|hormonal regulation of the force of heart contraction|
|positive regulation of the force of heart contraction by chemical signal|
|endothelin B receptor binding|
|positive regulation of prostaglandin-endoperoxide synthase activity|
|regulation of prostaglandin-endoperoxide synthase activity|
|vein smooth muscle contraction|
|regulation of the force of heart contraction by chemical signal|
|regulation of systemic arterial blood pressure by endothelin|
|artery smooth muscle contraction|
|tonic smooth muscle contraction|
|macrophage chemotaxis|
|vascular smooth muscle contraction|
|phasic smooth muscle contraction|
|prostanoid biosynthetic process|
|macrophage migration|
|prostaglandin biosynthetic process|
|inositol phosphate-mediated signaling|
|positive regulation of heart rate|
|regulation of the force of heart contraction|
|temperature homeostasis|
|positive regulation of smooth muscle contraction|
|vasoconstriction|
|energy homeostasis|
|prostanoid metabolic process|
|prostaglandin metabolic process|
|regulation of systemic arterial blood pressure by hormone|
|positive regulation of heart contraction|
|negative regulation of blood vessel diameter|
|lung alveolus development|
|unsaturated fatty acid biosynthetic process|
|positive regulation of muscle contraction|
|icosanoid biosynthetic process|
|regulation of systemic arterial blood pressure mediated by a chemical signal|
|endocrine process|
|macrophage activation|
|smooth muscle contraction|
|positive regulation of oxidoreductase activity|
|regulation of vasoconstriction|
|regulation of smooth muscle contraction|
|positive regulation of blood circulation|
|cell|
|neutrophil chemotaxis|
|positive regulation of leukocyte chemotaxis|
|granulocyte chemotaxis|
|fatty acid derivative biosynthetic process|
|neutrophil migration|
|regulation of systemic arterial blood pressure|
|regulation of oxidoreductase activity|
|regulation of heart rate|
|hormone activity|
|granulocyte migration|
|unsaturated fatty acid metabolic process|
|icosanoid metabolic process|
|regulation of leukocyte chemotaxis|
|fatty acid biosynthetic process|
|myeloid leukocyte migration|
|positive regulation of leukocyte migration|
|positive regulation of chemotaxis|
|regulation of tube diameter|
|regulation of blood vessel diameter|
|regulation of tube size|
|leukocyte chemotaxis|
|calcium-mediated signaling|
|regulation of muscle contraction|
|fatty acid derivative metabolic process|
|vascular process in circulatory system|
|lung development|
|respiratory tube development|
|regulation of blood pressure|
|monocarboxylic acid biosynthetic process|
|respiratory system development|
|regulation of leukocyte migration|
|cell chemotaxis|
|regulation of chemotaxis|
|regulation of muscle system process|
|regulation of heart contraction|
|muscle contraction|
|positive regulation of cytosolic calcium ion concentration|
|regulation of blood circulation|
|muscle system process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|fatty acid metabolic process|
|multicellular organismal homeostasis|
|regulation of cytosolic calcium ion concentration|
|second-messenger-mediated signaling|
|leukocyte migration|
|blood circulation|
|circulatory system process|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|positive regulation of cell migration|
|regulation of anatomical structure size|
|positive regulation of cell motility|
|monocarboxylic acid metabolic process|
|positive regulation of cellular component movement|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|cellular metal ion homeostasis|
|lipid biosynthetic process|
|myeloid leukocyte activation|
|regulation of system process|
|small molecule biosynthetic process|
|positive regulation of response to external stimulus|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cytokine-mediated signaling pathway|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|tube development|
|regulation of cell migration|
|cellular homeostasis|
|carboxylic acid metabolic process|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|leukocyte activation|
|cellular lipid metabolic process|
|cell migration|
|regulation of locomotion|
|regulation of cellular component movement|
|oxoacid metabolic process|
|cellular response to cytokine stimulus|
|organic acid metabolic process|
|cell activation|
|localization of cell|
|cell motility|
|regulation of response to external stimulus|
|response to cytokine|
|chemical homeostasis|
|positive regulation of immune system process|
|lipid metabolic process|
|locomotion|
|G protein-coupled receptor signaling pathway|
|positive regulation of catalytic activity|
|movement of cell or subcellular component|
|extracellular space|
|regulation of cell population proliferation|
|homeostatic process|
|regulation of immune system process|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|positive regulation of molecular function|
|extracellular region|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4987
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EDN2 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>