EDN3 [The Human Chemical-Genetic Interaction Map Project]

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======= EDN3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EDN3
  * **<color #00a2e8>Official Name</color>**: endothelin 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1908|1908]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P14138|P14138]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EDN3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EDN3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/131242|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Endothelins are endothelium-derived vasoconstrictor peptides.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Endothelin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endothelin B receptor binding|
|vein smooth muscle contraction|
|cellular magnesium ion homeostasis|
|regulation of systemic arterial blood pressure by endothelin|
|artery smooth muscle contraction|
|tonic smooth muscle contraction|
|magnesium ion homeostasis|
|regulation of developmental pigmentation|
|vascular smooth muscle contraction|
|phasic smooth muscle contraction|
|melanocyte differentiation|
|positive regulation of heart rate|
|inositol phosphate-mediated signaling|
|vasoconstriction|
|pigment cell differentiation|
|regulation of systemic arterial blood pressure by hormone|
|positive regulation of potassium ion transmembrane transport|
|positive regulation of heart contraction|
|negative regulation of blood vessel diameter|
|developmental pigmentation|
|positive regulation of potassium ion transport|
|regulation of systemic arterial blood pressure mediated by a chemical signal|
|endocrine process|
|smooth muscle contraction|
|positive regulation of mitotic nuclear division|
|neural crest cell migration|
|regulation of vasoconstriction|
|peptide hormone secretion|
|positive regulation of nuclear division|
|positive regulation of blood circulation|
|hormone secretion|
|neural crest cell development|
|regulation of potassium ion transmembrane transport|
|cell|
|hormone transport|
|neutrophil chemotaxis|
|mesenchymal cell development|
|stem cell development|
|positive regulation of leukocyte chemotaxis|
|neural crest cell differentiation|
|granulocyte chemotaxis|
|neutrophil migration|
|pigmentation|
|regulation of systemic arterial blood pressure|
|regulation of potassium ion transport|
|regulation of heart rate|
|hormone activity|
|granulocyte migration|
|regulation of leukocyte chemotaxis|
|myeloid leukocyte migration|
|positive regulation of hormone secretion|
|positive regulation of leukocyte migration|
|positive regulation of chemotaxis|
|regulation of tube diameter|
|regulation of blood vessel diameter|
|regulation of tube size|
|positive regulation of cation transmembrane transport|
|leukocyte chemotaxis|
|positive regulation of mitotic cell cycle|
|positive regulation of ion transmembrane transport|
|mesenchymal cell differentiation|
|stem cell differentiation|
|regulation of mitotic nuclear division|
|signal release|
|vascular process in circulatory system|
|ameboidal-type cell migration|
|peptide secretion|
|regulation of blood pressure|
|regulation of nuclear division|
|regulation of leukocyte migration|
|positive regulation of transmembrane transport|
|cell chemotaxis|
|regulation of chemotaxis|
|mesenchyme development|
|regulation of heart contraction|
|muscle contraction|
|positive regulation of MAP kinase activity|
|regulation of hormone secretion|
|positive regulation of ion transport|
|positive regulation of cell cycle process|
|regulation of blood circulation|
|muscle system process|
|regulation of cation transmembrane transport|
|signaling receptor binding|
|second-messenger-mediated signaling|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|positive regulation of cell cycle|
|leukocyte migration|
|regulation of metal ion transport|
|blood circulation|
|circulatory system process|
|positive regulation of secretion by cell|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|regulation of ion transmembrane transport|
|divalent inorganic cation homeostasis|
|positive regulation of cell migration|
|regulation of anatomical structure size|
|regulation of protein serine/threonine kinase activity|
|positive regulation of cell motility|
|positive regulation of protein kinase activity|
|regulation of hormone levels|
|positive regulation of cellular component movement|
|positive regulation of MAPK cascade|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|cellular metal ion homeostasis|
|regulation of transmembrane transport|
|positive regulation of kinase activity|
|regulation of system process|
|positive regulation of response to external stimulus|
|positive regulation of organelle organization|
|metal ion homeostasis|
|regulation of mitotic cell cycle|
|cellular cation homeostasis|
|cellular ion homeostasis|
|positive regulation of transferase activity|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of cell cycle process|
|ion homeostasis|
|regulation of protein kinase activity|
|regulation of secretion|
|regulation of cell migration|
|regulation of kinase activity|
|cellular homeostasis|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|cell migration|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|secretion by cell|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|export from cell|
|positive regulation of phosphorylation|
|localization of cell|
|cell motility|
|regulation of response to external stimulus|
|chemical homeostasis|
|cell-cell signaling|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of immune system process|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|regulation of organelle organization|
|locomotion|
|G protein-coupled receptor signaling pathway|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|generation of neurons|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|regulation of immune system process|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|nitrogen compound transport|
|regulation of transport|
|extracellular region|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7942
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EDN3 Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>