EEF1E1 [The Human Chemical-Genetic Interaction Map Project]

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======= EEF1E1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EEF1E1
  * **<color #00a2e8>Official Name</color>**: eukaryotic translation elongation factor 1 epsilon 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9521|9521]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43324|O43324]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EEF1E1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EEF1E1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609206|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Positive modulator of ATM response to DNA damage. {ECO:0000250|UniProtKB:Q9D1M4}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GST C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|aminoacyl-tRNA synthetase multienzyme complex|
|positive regulation of cellular senescence|
|positive regulation of cell aging|
|positive regulation of DNA damage response, signal transduction by p53 class mediator|
|positive regulation of signal transduction by p53 class mediator|
|regulation of DNA damage response, signal transduction by p53 class mediator|
|regulation of cellular senescence|
|tRNA aminoacylation for protein translation|
|regulation of cell aging|
|tRNA aminoacylation|
|amino acid activation|
|positive regulation of response to DNA damage stimulus|
|regulation of signal transduction by p53 class mediator|
|tRNA metabolic process|
|regulation of response to DNA damage stimulus|
|cellular amino acid metabolic process|
|translation|
|peptide biosynthetic process|
|ncRNA metabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|negative regulation of cell population proliferation|
|positive regulation of cell death|
|regulation of cellular response to stress|
|cellular amide metabolic process|
|nucleolus|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|positive regulation of intracellular signal transduction|
|organic acid metabolic process|
|positive regulation of developmental process|
|organonitrogen compound biosynthetic process|
|regulation of response to stress|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|positive regulation of signal transduction|
|RNA metabolic process|
|regulation of cell death|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|-2.19|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-1.78|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|-1.76|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|-1.7|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|1.88|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.15|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:thg1l|THG1L]]|0.545|
|[[:human genes:a:atxn10|ATXN10]]|0.524|
|[[:human genes:a:alg1|ALG1]]|0.516|
|[[:human genes:t:trmt10a|TRMT10A]]|0.502|
|[[:human genes:t:tmem41b|TMEM41B]]|0.501|
|[[:human genes:e:elp2|ELP2]]|0.496|
|[[:human genes:d:dpagt1|DPAGT1]]|0.494|
|[[:human genes:p:pdap1|PDAP1]]|0.483|
|[[:human genes:v:vezt|VEZT]]|0.479|
|[[:human genes:r:rnmt|RNMT]]|0.47|
|[[:human genes:r:rpp21|RPP21]]|0.467|
|[[:human genes:t:trmt5|TRMT5]]|0.466|
|[[:human genes:d:dhrsx|DHRSX]]|0.463|
|[[:human genes:t:tsen54|TSEN54]]|0.458|
|[[:human genes:c:c14orf166|C14orf166]]|0.457|
|[[:human genes:t:tprkb|TPRKB]]|0.455|
|[[:human genes:r:rtcb|RTCB]]|0.455|
|[[:human genes:p:pmm2|PMM2]]|0.454|
|[[:human genes:u:urm1|URM1]]|0.453|
|[[:human genes:t:ttc4|TTC4]]|0.453|
|[[:human genes:p:ppcs|PPCS]]|0.451|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.45|
|[[:human genes:t:ten1|TEN1]]|0.45|
|[[:human genes:e:eif1ax|EIF1AX]]|0.449|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.448|
|[[:human genes:p:polr3h|POLR3H]]|0.448|
|[[:human genes:h:haus8|HAUS8]]|0.447|
|[[:human genes:r:rptor|RPTOR]]|0.445|
|[[:human genes:d:dohh|DOHH]]|0.443|
|[[:human genes:s:ssb|SSB]]|0.438|
|[[:human genes:s:sec62|SEC62]]|0.435|
|[[:human genes:a:asb7|ASB7]]|0.434|
|[[:human genes:a:atp5j|ATP5J]]|0.431|
|[[:human genes:c:crcp|CRCP]]|0.429|
|[[:human genes:t:tpk1|TPK1]]|0.428|
|[[:human genes:u:uap1|UAP1]]|0.427|
|[[:human genes:t:trmt61a|TRMT61A]]|0.426|
|[[:human genes:d:dhps|DHPS]]|0.425|
|[[:human genes:d:dolk|DOLK]]|0.425|
|[[:human genes:s:srp68|SRP68]]|0.422|
|[[:human genes:m:med4|MED4]]|0.422|
|[[:human genes:e:exoc4|EXOC4]]|0.421|
|[[:human genes:t:triap1|TRIAP1]]|0.42|
|[[:human genes:a:aars|AARS]]|0.42|
|[[:human genes:e:elp3|ELP3]]|0.42|
|[[:human genes:m:maml1|MAML1]]|0.418|
|[[:human genes:d:ddx1|DDX1]]|0.418|
|[[:human genes:m:mbtps2|MBTPS2]]|0.418|
|[[:human genes:l:lsm10|LSM10]]|0.418|
|[[:human genes:p:pyroxd1|PYROXD1]]|0.418|
|[[:human genes:g:gemin6|GEMIN6]]|0.418|
|[[:human genes:a:alg6|ALG6]]|0.417|
|[[:human genes:a:alg2|ALG2]]|0.417|
|[[:human genes:p:paxip1|PAXIP1]]|0.416|
|[[:human genes:d:dr1|DR1]]|0.415|
|[[:human genes:u:uhrf1|UHRF1]]|0.415|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.413|
|[[:human genes:s:slc25a19|SLC25A19]]|0.413|
|[[:human genes:p:polr3b|POLR3B]]|0.411|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.411|
|[[:human genes:p:pelo|PELO]]|0.411|
|[[:human genes:p:polr3c|POLR3C]]|0.409|
|[[:human genes:c:ccdc101|CCDC101]]|0.409|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.408|
|[[:human genes:s:srp14|SRP14]]|0.408|
|[[:human genes:g:gmppb|GMPPB]]|0.406|
|[[:human genes:f:fh|FH]]|0.405|
|[[:human genes:o:osgep|OSGEP]]|0.403|
|[[:human genes:e:elp6|ELP6]]|0.401|
|[[:human genes:t:tbcb|TBCB]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2598
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EEF1E1 Expression in NALM6 Cells: 5.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>