EEF1G [The Human Chemical-Genetic Interaction Map Project]

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======= EEF1G =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EEF1G
  * **<color #00a2e8>Official Name</color>**: eukaryotic translation elongation factor 1 gamma
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1937|1937]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P26641|P26641]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EEF1G&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EEF1G|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/130593|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Probably plays a role in anchoring the complex to other cellular components.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|EF1G|
|GST N|
|GST C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|translation elongation factor activity|
|translational elongation|
|response to virus|
|cadherin binding|
|translation|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|endoplasmic reticulum|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 424/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|22/28|
|blood|12/28|
|bone|14/26|
|breast|15/33|
|central nervous system|35/56|
|cervix|2/4|
|colorectal|4/17|
|esophagus|9/13|
|fibroblast|0/1|
|gastric|12/16|
|kidney|13/21|
|liver|17/20|
|lung|39/75|
|lymphocyte|7/16|
|ovary|14/26|
|pancreas|8/24|
|peripheral nervous system|8/16|
|plasma cell|3/15|
|prostate|1/1|
|skin|16/24|
|soft tissue|8/9|
|thyroid|1/2|
|upper aerodigestive|15/22|
|urinary tract|20/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1580
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EEF1G Expression in NALM6 Cells: 9.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>