EEF2 [The Human Chemical-Genetic Interaction Map Project]

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======= EEF2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EEF2
  * **<color #00a2e8>Official Name</color>**: eukaryotic translation elongation factor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1938|1938]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P13639|P13639]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EEF2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EEF2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/130610|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|EFG IV|
|GTP EFTU D2|
|EFG C|
|GTP EFTU|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular response to brain-derived neurotrophic factor stimulus|
|response to folic acid|
|positive regulation of cytoplasmic translation|
|5S rRNA binding|
|glial cell proliferation|
|translation elongation factor activity|
|skeletal muscle contraction|
|regulation of cytoplasmic translation|
|polysomal ribosome|
|aggresome|
|multicellular organismal movement|
|musculoskeletal movement|
|response to ischemia|
|cellular response to nerve growth factor stimulus|
|skeletal muscle cell differentiation|
|response to nerve growth factor|
|ribosome binding|
|p53 binding|
|response to vitamin|
|hematopoietic progenitor cell differentiation|
|striated muscle contraction|
|secretory granule lumen|
|response to hydrogen peroxide|
|translational elongation|
|skeletal muscle tissue development|
|ficolin-1-rich granule lumen|
|positive regulation of translation|
|response to ethanol|
|skeletal muscle organ development|
|response to estradiol|
|positive regulation of cellular amide metabolic process|
|ribonucleoprotein complex|
|response to reactive oxygen species|
|actin filament binding|
|gliogenesis|
|response to nutrient|
|membrane raft|
|response to alcohol|
|muscle contraction|
|response to endoplasmic reticulum stress|
|synapse|
|aging|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|muscle system process|
|response to antibiotic|
|cadherin binding|
|GTPase activity|
|response to acid chemical|
|regulation of translation|
|translation|
|response to oxidative stress|
|GTP binding|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|protein kinase binding|
|muscle structure development|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|response to nutrient levels|
|cellular response to growth factor stimulus|
|neutrophil activation|
|granulocyte activation|
|response to toxic substance|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|response to extracellular stimulus|
|response to growth factor|
|response to inorganic substance|
|cell population proliferation|
|hemopoiesis|
|myeloid leukocyte activation|
|hematopoietic or lymphoid organ development|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|immune system development|
|regulated exocytosis|
|leukocyte mediated immunity|
|cellular amide metabolic process|
|exocytosis|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|leukocyte activation|
|response to organonitrogen compound|
|secretion by cell|
|response to drug|
|export from cell|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|secretion|
|cellular response to endogenous stimulus|
|RNA binding|
|organonitrogen compound biosynthetic process|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|tissue development|
|macromolecule biosynthetic process|
|immune response|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|vesicle-mediated transport|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-2.63|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-2.3|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|-2.21|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-2.2|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|-2.07|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|-2.04|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-1.95|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|-1.9|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-1.9|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|-1.87|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.84|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-1.82|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-1.78|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-1.75|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-1.74|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-1.71|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|2.66|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 739/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 44
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 11.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EEF2 Expression in NALM6 Cells: 11.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>