EFTUD1 [The Human Chemical-Genetic Interaction Map Project]

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======= EFTUD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EFL1
  * **<color #00a2e8>Official Name</color>**: elongation factor like GTPase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79631|79631]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z2Z2|Q7Z2Z2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EFTUD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EFTUD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617538|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits. {ECO:0000269|PubMed:21536732}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|EFG C|
|GTP EFTU|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mature ribosome assembly|
|translation elongation factor activity|
|GTP metabolic process|
|guanosine-containing compound metabolic process|
|ribosome binding|
|purine ribonucleoside triphosphate metabolic process|
|purine ribonucleoside metabolic process|
|purine nucleoside metabolic process|
|ribosome assembly|
|ribonucleoside triphosphate metabolic process|
|purine nucleoside triphosphate metabolic process|
|ribonucleoside metabolic process|
|nucleoside triphosphate metabolic process|
|nucleoside metabolic process|
|translational elongation|
|glycosyl compound metabolic process|
|ribonucleoprotein complex|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|ribosome biogenesis|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|GTPase activity|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|translation|
|GTP binding|
|peptide biosynthetic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|ribonucleoprotein complex biogenesis|
|amide biosynthetic process|
|peptide metabolic process|
|nucleobase-containing small molecule metabolic process|
|organelle assembly|
|cellular amide metabolic process|
|cellular protein-containing complex assembly|
|organophosphate metabolic process|
|carbohydrate derivative metabolic process|
|organonitrogen compound biosynthetic process|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|-1.73|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.72|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.73|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|1.75|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|1.82|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.83|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|1.84|
|[[:results:exp274|Citral 50μM R06 exp274]]|1.89|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|2.1|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.24|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:sbds|SBDS]]|0.541|
|[[:human genes:e:eif3f|EIF3F]]|0.498|
|[[:human genes:t:ten1|TEN1]]|0.468|
|[[:human genes:t:thg1l|THG1L]]|0.456|
|[[:human genes:g:gmppb|GMPPB]]|0.451|
|[[:human genes:r:rpp21|RPP21]]|0.445|
|[[:human genes:m:msto1|MSTO1]]|0.438|
|[[:human genes:h:hars|HARS]]|0.434|
|[[:human genes:u:urm1|URM1]]|0.434|
|[[:human genes:a:adsl|ADSL]]|0.433|
|[[:human genes:e:elp2|ELP2]]|0.424|
|[[:human genes:t:txnl4b|TXNL4B]]|0.422|
|[[:human genes:a:atxn10|ATXN10]]|0.421|
|[[:human genes:p:pmm2|PMM2]]|0.415|
|[[:human genes:v:vezt|VEZT]]|0.414|
|[[:human genes:g:gtf3a|GTF3A]]|0.414|
|[[:human genes:c:c1orf27|C1orf27]]|0.407|
|[[:human genes:t:tma16|TMA16]]|0.405|
|[[:human genes:e:eif1ax|EIF1AX]]|0.403|
|[[:human genes:a:asb3|ASB3]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 284/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|14/28|
|blood|7/28|
|bone|8/26|
|breast|13/33|
|central nervous system|23/56|
|cervix|1/4|
|colorectal|10/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|5/16|
|kidney|10/21|
|liver|11/20|
|lung|31/75|
|lymphocyte|5/16|
|ovary|15/26|
|pancreas|13/24|
|peripheral nervous system|8/16|
|plasma cell|5/15|
|prostate|0/1|
|skin|9/24|
|soft tissue|5/9|
|thyroid|0/2|
|upper aerodigestive|10/22|
|urinary tract|13/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2884
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EFTUD1 Expression in NALM6 Cells: 5.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>