EHD2 [The Human Chemical-Genetic Interaction Map Project]

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======= EHD2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EHD2
  * **<color #00a2e8>Official Name</color>**: EH domain containing 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=30846|30846]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NZN4|Q9NZN4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EHD2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EHD2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605890|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (By similarity). Plays a role in membrane trafficking between the plasma membrane and endosomes (PubMed:17233914). Important for the internalization of GLUT4. Required for fusion of myoblasts to skeletal muscle myotubes. Required for normal translocation of FER1L5 to the plasma membrane (By similarity). Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by constraining caveolae at the cell membrane (PubMed:25588833). {ECO:0000250|UniProtKB:Q8BH64, ECO:0000269|PubMed:17233914, ECO:0000269|PubMed:25588833}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Dynamin N|
|efhand 3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of endocytic recycling|
|regulation of endocytic recycling|
|plasma membrane tubulation|
|positive regulation of myoblast fusion|
|regulation of myoblast fusion|
|positive regulation of syncytium formation by plasma membrane fusion|
|regulation of syncytium formation by plasma membrane fusion|
|positive regulation of myotube differentiation|
|endocytic recycling|
|cortical actin cytoskeleton organization|
|cortical cytoskeleton organization|
|regulation of myotube differentiation|
|positive regulation of striated muscle cell differentiation|
|intercellular bridge|
|extrinsic component of membrane|
|caveola|
|hydrolase activity|
|recycling endosome membrane|
|positive regulation of muscle cell differentiation|
|plasma membrane organization|
|regulation of striated muscle cell differentiation|
|microtubule cytoskeleton|
|regulation of muscle cell differentiation|
|protein localization to plasma membrane|
|nucleic acid binding|
|positive regulation of intracellular transport|
|endosome membrane|
|endosomal transport|
|protein localization to cell periphery|
|protein domain specific binding|
|blood coagulation|
|coagulation|
|hemostasis|
|regulation of intracellular transport|
|GTP binding|
|endomembrane system organization|
|wound healing|
|protein localization to membrane|
|actin cytoskeleton organization|
|regulation of body fluid levels|
|regulation of vesicle-mediated transport|
|endocytosis|
|actin filament-based process|
|response to wounding|
|import into cell|
|perinuclear region of cytoplasm|
|calcium ion binding|
|membrane organization|
|regulation of cellular localization|
|positive regulation of cell differentiation|
|positive regulation of transport|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|cytoskeleton organization|
|positive regulation of cellular component organization|
|positive regulation of developmental process|
|ATP binding|
|intracellular transport|
|cellular protein localization|
|cellular macromolecule localization|
|regulation of cell differentiation|
|establishment of localization in cell|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15131
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.78 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EHD2 Expression in NALM6 Cells: 1.78'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>