EIF2B2 [The Human Chemical-Genetic Interaction Map Project]

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======= EIF2B2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EIF2B2
  * **<color #00a2e8>Official Name</color>**: eukaryotic translation initiation factor 2B subunit beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8892|8892]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49770|P49770]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EIF2B2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EIF2B2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606454|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the beta subunit of eukaryotic initiation factor-2B (EIF2B). EIF2B is involved in protein synthesis and exchanges GDP and GTP for its activation and deactivation. [provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IF-2B|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|eukaryotic translation initiation factor 2B complex|
|oligodendrocyte development|
|ovarian follicle development|
|translation initiation factor activity|
|oligodendrocyte differentiation|
|regulation of translational initiation|
|female gonad development|
|development of primary female sexual characteristics|
|guanyl-nucleotide exchange factor activity|
|myelination|
|glial cell development|
|female sex differentiation|
|ensheathment of neurons|
|axon ensheathment|
|response to heat|
|response to glucose|
|translational initiation|
|response to hexose|
|response to monosaccharide|
|glial cell differentiation|
|response to carbohydrate|
|T cell receptor signaling pathway|
|response to temperature stimulus|
|gonad development|
|gliogenesis|
|development of primary sexual characteristics|
|sex differentiation|
|antigen receptor-mediated signaling pathway|
|regulation of translation|
|translation|
|GTP binding|
|response to peptide hormone|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|reproductive structure development|
|reproductive system development|
|immune response-activating cell surface receptor signaling pathway|
|response to peptide|
|immune response-regulating cell surface receptor signaling pathway|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|activation of immune response|
|developmental process involved in reproduction|
|cellular amide metabolic process|
|positive regulation of immune response|
|response to hormone|
|central nervous system development|
|response to organonitrogen compound|
|response to nitrogen compound|
|positive regulation of immune system process|
|regulation of immune response|
|response to abiotic stimulus|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|ATP binding|
|response to oxygen-containing compound|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|cell development|
|regulation of immune system process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp246|UM0011500 10μM R05 exp246]]|1.77|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 641/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|21/28|
|blood|26/28|
|bone|21/26|
|breast|32/33|
|central nervous system|52/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|11/13|
|fibroblast|1/1|
|gastric|11/16|
|kidney|19/21|
|liver|20/20|
|lung|62/75|
|lymphocyte|13/16|
|ovary|22/26|
|pancreas|16/24|
|peripheral nervous system|15/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|21/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|17/22|
|urinary tract|23/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 869
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EIF2B2 Expression in NALM6 Cells: 4.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>