EIF2B4 [The Human Chemical-Genetic Interaction Map Project]

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======= EIF2B4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EIF2B4
  * **<color #00a2e8>Official Name</color>**: eukaryotic translation initiation factor 2B subunit delta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8890|8890]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UI10|Q9UI10]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EIF2B4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EIF2B4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606687|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta, subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IF-2B|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|eukaryotic translation initiation factor 2B complex|
|translation initiation factor binding|
|oligodendrocyte development|
|ovarian follicle development|
|translation initiation factor activity|
|oligodendrocyte differentiation|
|female gonad development|
|development of primary female sexual characteristics|
|guanyl-nucleotide exchange factor activity|
|myelination|
|glial cell development|
|female sex differentiation|
|ensheathment of neurons|
|axon ensheathment|
|response to heat|
|response to glucose|
|translational initiation|
|response to hexose|
|response to monosaccharide|
|glial cell differentiation|
|response to carbohydrate|
|T cell receptor signaling pathway|
|response to temperature stimulus|
|gonad development|
|gliogenesis|
|development of primary sexual characteristics|
|sex differentiation|
|antigen receptor-mediated signaling pathway|
|regulation of translation|
|translation|
|response to peptide hormone|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|reproductive structure development|
|reproductive system development|
|immune response-activating cell surface receptor signaling pathway|
|response to peptide|
|immune response-regulating cell surface receptor signaling pathway|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|activation of immune response|
|developmental process involved in reproduction|
|cellular amide metabolic process|
|positive regulation of immune response|
|response to hormone|
|central nervous system development|
|response to organonitrogen compound|
|response to nitrogen compound|
|positive regulation of immune system process|
|regulation of immune response|
|response to abiotic stimulus|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|cell development|
|regulation of immune system process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp116|AICAR 240μM R03 exp116]]|-1.78|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|1.7|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|1.71|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|1.72|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|1.74|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|1.76|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|1.78|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|1.83|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|1.83|
|[[:results:exp302|35°C R06 exp302]]|1.86|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.91|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|2.12|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|2.18|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|2.3|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:ppp1r15b|PPP1R15B]]|0.477|
|[[:human genes:e:eif2b5|EIF2B5]]|0.415|
|[[:human genes:d:dnajc16|DNAJC16]]|0.412|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 297/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|8/28|
|blood|11/28|
|bone|9/26|
|breast|12/33|
|central nervous system|24/56|
|cervix|1/4|
|colorectal|9/17|
|esophagus|6/13|
|fibroblast|0/1|
|gastric|10/16|
|kidney|12/21|
|liver|6/20|
|lung|29/75|
|lymphocyte|11/16|
|ovary|10/26|
|pancreas|6/24|
|peripheral nervous system|9/16|
|plasma cell|6/15|
|prostate|1/1|
|skin|4/24|
|soft tissue|5/9|
|thyroid|1/2|
|upper aerodigestive|7/22|
|urinary tract|12/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 700
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EIF2B4 Expression in NALM6 Cells: 5.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>