EIF2S3 [The Human Chemical-Genetic Interaction Map Project]

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======= EIF2S3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EIF2S3
  * **<color #00a2e8>Official Name</color>**: eukaryotic translation initiation factor 2 subunit gamma
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1968|1968]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P41091|P41091]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EIF2S3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EIF2S3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300161|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is the largest subunit of a heterotrimeric GTP-binding protein involved in the recruitment of methionyl-tRNA(i) to the 40 S ribosomal subunit. [provided by RefSeq, Jan 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (By similarity). Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q9Z0N1}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GTP EFTU D2|
|eIF2 C|
|GTP EFTU|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of translational fidelity|
|eukaryotic translation initiation factor 2 complex|
|formation of translation preinitiation complex|
|regulation of translational fidelity|
|translation factor activity, RNA binding|
|cytoplasmic translational initiation|
|translation initiation factor activity|
|tRNA binding|
|cytoplasmic translation|
|positive regulation of translation|
|translational initiation|
|positive regulation of cellular amide metabolic process|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|cadherin binding|
|GTPase activity|
|regulation of translation|
|translation|
|GTP binding|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|ribonucleoprotein complex biogenesis|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|cellular protein-containing complex assembly|
|transmembrane transport|
|organonitrogen compound biosynthetic process|
|protein-containing complex assembly|
|positive regulation of cellular protein metabolic process|
|cellular nitrogen compound biosynthetic process|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-1.75|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.71|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|1.78|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|1.81|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|1.84|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.85|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|1.92|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|2.54|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 694/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|26/26|
|bone|26/26|
|breast|30/30|
|central nervous system|49/49|
|cervix|4/4|
|colorectal|17/17|
|esophagus|11/11|
|fibroblast|1/1|
|gastric|14/14|
|kidney|18/18|
|liver|19/19|
|lung|72/72|
|lymphocyte|16/16|
|ovary|25/25|
|pancreas|22/22|
|peripheral nervous system|15/15|
|plasma cell|12/12|
|prostate|1/1|
|skin|20/20|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/28|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 556
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.82 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EIF2S3 Expression in NALM6 Cells: 7.82'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>