EIF3D [The Human Chemical-Genetic Interaction Map Project]

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======= EIF3D =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EIF3D
  * **<color #00a2e8>Official Name</color>**: eukaryotic translation initiation factor 3 subunit D
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8664|8664]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15371|O15371]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EIF3D&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EIF3D|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603915|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs (PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:18599441, PubMed:25849773). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs (PubMed:27462815). {ECO:0000269|PubMed:18599441, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|eIF-3 zeta|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cap-dependent translational initiation|
|mRNA cap binding|
|viral translational termination-reinitiation|
|eukaryotic translation initiation factor 3 complex, eIF3m|
|positive regulation of mRNA binding|
|positive regulation of RNA binding|
|regulation of mRNA binding|
|IRES-dependent viral translational initiation|
|regulation of RNA binding|
|viral translation|
|eukaryotic 48S preinitiation complex|
|eukaryotic translation initiation factor 3 complex|
|formation of cytoplasmic translation initiation complex|
|eukaryotic 43S preinitiation complex|
|cytoplasmic translational initiation|
|translation initiation factor activity|
|cytoplasmic translation|
|positive regulation of translation|
|viral gene expression|
|translational initiation|
|positive regulation of cellular amide metabolic process|
|positive regulation of binding|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|regulation of translation|
|regulation of binding|
|translation|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|ribonucleoprotein complex biogenesis|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|viral process|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|cellular protein-containing complex assembly|
|RNA binding|
|organonitrogen compound biosynthetic process|
|protein-containing complex assembly|
|positive regulation of cellular protein metabolic process|
|cellular nitrogen compound biosynthetic process|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|protein-containing complex subunit organization|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.78|
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|1.7|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|1.71|
|[[:results:exp115|A-366 10μM R03 exp115]]|1.74|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|1.98|
|[[:results:exp131|L-74142 5μM R03 exp131]]|1.99|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.01|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|2.01|
|[[:results:exp218|A-395 10μM R05 exp218]]|2.05|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|2.15|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|2.19|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 667/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|26/28|
|blood|26/28|
|bone|24/26|
|breast|31/33|
|central nervous system|51/56|
|cervix|3/4|
|colorectal|17/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|14/16|
|kidney|15/21|
|liver|18/20|
|lung|66/75|
|lymphocyte|16/16|
|ovary|24/26|
|pancreas|20/24|
|peripheral nervous system|15/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|19/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|26/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1253
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.76 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EIF3D Expression in NALM6 Cells: 7.76'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>