EIF3H [The Human Chemical-Genetic Interaction Map Project]

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======= EIF3H =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EIF3H
  * **<color #00a2e8>Official Name</color>**: eukaryotic translation initiation factor 3 subunit H
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8667|8667]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15372|O15372]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EIF3H&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EIF3H|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603912|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF- 3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03007, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mov34|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|eukaryotic translation initiation factor 3 complex, eIF3m|
|eukaryotic 48S preinitiation complex|
|eukaryotic translation initiation factor 3 complex|
|formation of cytoplasmic translation initiation complex|
|eukaryotic 43S preinitiation complex|
|cytoplasmic translational initiation|
|polysomal ribosome|
|translation initiation factor activity|
|metallopeptidase activity|
|cytoplasmic translation|
|regulation of translational initiation|
|translational initiation|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|regulation of translation|
|translation|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|ribonucleoprotein complex biogenesis|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|cellular protein-containing complex assembly|
|proteolysis|
|RNA binding|
|organonitrogen compound biosynthetic process|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-3.14|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-2.44|
|[[:results:exp539|42°C R08 exp539]]|-2.13|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|-1.72|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.76|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|1.78|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|1.78|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|1.8|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|1.82|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|1.88|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.95|
|[[:results:exp275|Citral 75μM R06 exp275]]|1.96|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.04|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|2.05|
|[[:results:exp274|Citral 50μM R06 exp274]]|2.31|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|2.31|
|[[:results:exp534|Trientine 500μM R08 exp534]]|2.42|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|2.48|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|2.62|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.78|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|3.1|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|3.34|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|3.99|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|4.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.502|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 286/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|8/28|
|blood|6/28|
|bone|12/26|
|breast|11/33|
|central nervous system|30/56|
|cervix|1/4|
|colorectal|8/17|
|esophagus|2/13|
|fibroblast|1/1|
|gastric|5/16|
|kidney|4/21|
|liver|10/20|
|lung|27/75|
|lymphocyte|6/16|
|ovary|9/26|
|pancreas|9/24|
|peripheral nervous system|14/16|
|plasma cell|5/15|
|prostate|1/1|
|skin|13/24|
|soft tissue|3/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|9/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2226
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EIF3H Expression in NALM6 Cells: 7.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>